ObjectiveThe aim of the study reported here was to assess the disease-free survival and overall survival
of patients with endometrial cancer and to determine independent factors affecting the
prognosis.Materials and methodsThis was a retrospective study of a single-center clinical series of 276 patients (mean age 64
years) with histologically confirmed cancer of the corpus uteri. The standard treatments were
extrafascial total hysterectomy and bilateral salpingo-oophorectomy with selective
pelvic/para-aortic node dissection, according to risk for recurrence. Actuarial overall survival and
disease-free survival were estimated according to the Kaplan–Meier method. Univariate and
multivariate Cox proportional hazards analyses were used to assess the prognostic significance of
the different variables.ResultsThe estimated median follow-up, determined using the inverse Kaplan–Meier method, was 45
months (95% confidence interval [CI] 41.2–48.8) for disease-free survival
and 46 months (95% CI 43.0–49.0) for overall survival. The statistically significant
variables affecting disease-free survival and overall survival were age, serous-papillary and
clear-cell histological types, outer-half myometrial invasion, advanced International Federation of
Gynecology and Obstetrics (FIGO) stage, tumor grades G2 and G3, incomplete surgical resection,
positive lymph nodes, lymphovascular space invasion, tumor remnants of >1 cm after surgery,
and high-risk group. In the multivariate Cox regression model, predictors of tumor recurrence
included advanced FIGO stage (hazard ratio [HR] 4.90, 95% CI 2.57–9.36,
P < 0.001) and tumor grades G2 (HR 4.79, 95% CI 1.73–13.27,
P = 0.003) and G3 (HR 7.56, 95% CI 2.75–20.73, P <
0.001). The same variables were also associated with a significantly higher risk of tumor-related
mortality.ConclusionFIGO stage and tumor grade were independent prognostic factors of disease-free survival and
overall survival in endometrial cancer patients. Outcome was also influenced by histopathologic
type, myometrial and lymphovascular space invasion, lymph-node involvement, age, and tumor remnants
after surgery, although a larger study sample is probably needed to demonstrate the independent
association of these variables with survival.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.