A within-host tuberculosis model describing the interaction between macrophages and Mycobacterium tuberculosis was developed and analyzed in this paper. We derive R 0 as the threshold value of the model and analyze the existence and stability of equilibrium points. Furthermore, bifurcation analysis performed based on the use of the application of the center manifold theory. Explicit condition for the existence of backward bifurcation is given. Finally, numerical simulations are presented to support the theoretical findings.