Aristolochia longa is widely used in traditional medicine in Algeria to treat breast cancer. The aim of the present study was to investigate the response of bone resorption markers to A. longa intake by Algerian breast cancer postmenopausal women. According to the A. longa intake, breast cancer patients were grouped into A. longa group (Al) (n = 54) and non-A. longa group (non-Al) (n = 24). 32 women constituted the control group. Bone resorption markers (from urine) pyridinoline (PYD) and deoxypyridinoline (DPD) were determined by HPLC. Serum and urinary creatinine, uric acid, and urea were measured. 1 g of A. longa intake resulted in significant rise of renal serum markers and a pronounced increase of bone resorption markers. The intake of A. longa roots is detrimental for kidney function and resulted in high bone resorption, maybe due to the reduction in renal function caused by the aristolochic acids contained in the roots.

Background In front of the polymorphic bacterial ecology and antibiotic resistance in diabetic patients with foot infections and good patient care, collaboration between clinicians and microbiologists is needed to improve assessment and management of patients with this pathology. Objective This study was designed to characterize the bacterial ecology of diabetic foot infection (DFIs) and to determine the different mechanisms of resistance involved. Methods In this study bacterial strains and antibiotic resistance profiles were determined from diabetic foot infections patients (n = 117). The identification of resistance mechanisms, such as penicillinase and/or extended-spectrum β-lactamase production (ESBL), methicillin-resistant Staphylococcus aureus (MRSA) and efflux pump over-expression were performed. Results A high prevalence of Gram-negative bacteria (61%) with Escherichia coli, and other Enterobacteriaceae and Pseudomonas aeruginosa being the predominant isolates. Gram positive bacteria mainly represented by Staphylococcus aureus accounted for 39% of the isolates. 93.5% of the Enterobacteriaceae were resistant to, at least, one molecule in the β-lactam family, while the majority of the Staphylococci were resistant to penicillin G and tetracycline (93.3% and 71.7%). The majority of non-fermenting Gram negative bacteria were also resistant to fluoroquinolones. β-lactamase detection tests revealed the presence of extended-spectrum β-lactamase in 43.5% of the Enterobacteriaceae, while methicillin-resistant Staphylococcus aureus represented 18.2% of the isolates. Additionally, 50.9% of non-fermenting Gram negative bacteria were overproducing efflux pumps. Conclusion All Acinetobacter Baumannii were Multidrug-Resistant (MDR), as the majority of Staphylococci, and Enterobacteriaceae. These results should be taken into account by the clinician in the prescription of probabilistic antibiotic therapy in this context.

Due to rapid growth of the food processing industry and the consumption of processed foods, the demand for natural antimicrobial agents is on the rise. Cons aware about the health effects of the synthetic preservatives used in food. Hence natural preservatives are developed to meet the demand of consumers. These natural antimicrobials are developed either from plants or their parts, anim waste generated from the food industries is being considered as an alternative to produce natural antimicrobials. The aim of the present study was to utilize the waste generated from the citrus fruit processing (peel) i of Citrus sinensis in food (Oil of olive and cream dessert can be used as antimicrobial and

Le cancer colorectal est le troisième cancer dans le monde chez les deux sexes confondus. Quatre cents mille décès par cancer colorectal sont enregistrés chaque année. Ce type de cancer constitue de plus en plus un problème majeur de santé publique en Algérie. Notre travail repose sur une étude rétrospective dans le but de déterminer les cas de cancer colorectal à travers l'Ouest algérien. L'étude épidémiologique a été réalisée sur une période allant de 2000 à 2006. L'échantillonnage comporte 501 patients atteints de cancer du côlon (272 hommes, soit 54 % et 229 femmes, soit 46 %). Les résultats obtenus ont révélé une légère pré-dominance masculine avec un sex-ratio de 1,2, une fréquence élevée de l'atteinte maligne du côlon gauche (61,8 %) par rapport au côlon droit (38,2 %), respectivement. Selon la classification de Dukes, 58 % des patients présentent des tumeurs aux stades C et D. En conclusion, le type côlon gauche domine dans les deux sexes par rapport à la localisation du côlon droit et cela au niveau des différentes wilayas (Oran, Sidi-Bel-Abbes, Mascara, Ain-Temouchent et Relizane). Les résultats obtenus à l'issue de cette étude nous renseignent seulement sur la situation épidémiologique du cancer du côlon à travers l'Ouest algérien. À cet effet, il serait fort intéressant de réaliser une enquête nutritionnelle afin de déterminer le rôle important de l'alimentation dans l'étiologie de ce type de cancer. Mots clés Cancer du côlon · Épidémiologie · Prévention primaireAbstract Colorectal cancer is the world's third most common cancer, when both sexes are considered together. 400,000 deaths from colorectal cancer are recorded every year. This type of cancer is an increasingly significant problem for public health in Algeria. The aim of our work, which took the form of a retrospective study, was to determine the number of cases of colorectal cancer in western Algeria. The epidemiological study took place between 2000 and 2006. The sample included 501 patients with colon cancer (272 men or 54% and 229 women or 46%). The results obtained showed a slight masculine predominance with a sex ratio of 1.2, and a higher rate of malignancy in the left colon (61.8%) in comparison with the right colon (38.2%). According to Dukes classification, 58% of patients presented tumours in C and D stages. In conclusion, cancer of the left colon was more common in both sexes in comparison with localisation in the right colon, in all the various wilayas (Oran, Sidi-Bel-Abbes, Mascara, Ain-Temouchent and Relizane). The results of this study only tell us about the epidemiological situation concerning colon cancer in western Algeria. A study of nutrition in this part of Algeria might well give an interesting insight into the considerable effect of diet in the etiology of this type of cancer.