Aim. Evaluation of the efficacy, safety, and tolerability of Riamilovir (trade name «Triazavirin®») in patients with mild COVID-19.Materials and methods. The randomized open-label study included 120 patients with clinical and epidemiological manifestations of coronavirus infection and its laboratory (PCR) confirmation.Results. The efficacy, safety, as well as good tolerability of Riamilovir in the treatment of new coronavirus infection (COVID-19) have been established.Conclusion. The results of the study on the efficacy, safety, and tolerability of Riamilovir allow us to recommend it as a means of etiotropic therapy of the new coronavirus infection (COVID-19).

The aim of the study was to carry out meta-analysis of randomized controlled trials in order to combine the results of clinical trials on Triazavirin® (Riamilovir) efficacy in the etiotropic therapy of acute respiratory viral infection. Materials and methods. The studies included 435 patients with a confirmed diagnosis of acute respiratory viral infection or ARVI (with laboratory confirmed absence of influenza virus antigens). The research was carried out in 27 centers. In studies, patients were divided into 3 groups in a 1:1:1 ratio (a total of 145 people per group). Each study included a group taking 100 mg of the medication 5 times a day, a group taking 250 mg of the medication 3 times a day and a placebo 2 times a day, as well as a group taking a placebo 5 times a day. The analysis was carried out in accordance with the PRISMA principles regarding the quality of information presentation on the results of systematic reviews and meta-analyzes of works evaluating the effects of medical interventions. Results. The conducted meta-analysis showed that the use of Triazavirin® (Riamilovir) has a statistically significantly effects on the severity of clinical symptoms in patients with ARVI. The performed meta-analysis confirmed reliable associations between the use of Triazavirin® (Riamilovir) in both doses and the chance of a persistent improvement in clinical symptoms on the 5th day of therapy. The meta-analysis also confirmed the statistical significance of the clinical effects of Riamilovir by such indicators as the area under the curve «point on the scale showing the severity of the condition in a patient with ARVI in relation to time», the proportion of patients with complete alleviation of all symptoms by the end of the 5th day from the start of therapy. Conclusion. The clinical trials proved that the use of Triazavirin® (Riamilovir) is effective both in the initial and in the late stages of the disease, therefore, the drug can be used in the initial therapy of adult patients with respiratory diseases of viral etiology.

Статья посвящена профилактике пневмококковых инфекций, которые являются одними из ведущих в структуре заболеваемости детей раннего возраста. Учитывая включение вакцинации против данной инфекции в российский Национальный календарь профилактических прививок, в свете прогнозирования ожидаемого эффекта массовой иммунизации авторы анализируют международные подходы к оценке результативности вакцинации. Обсуждаются сложности трактовки эпидемиологических, иммунологических и клинических данных при отсутствии исследований по прямому сравнению препаратов. Показана необходимость многокомпонентного подхода к оценке эффективности программ иммунизации, включающего оптимизацию эпидемиологического надзора, утверждение стандартного определения случая, учет результатов предрегистрационных клинических исследований вакцин и пострегистрационного наблюдения в сходных популяциях.

On 01.07.2019, more than 1, 000 children were diagnosed with HIV infection in the Sverdlovsk region. Studies on the prevalence of dermatoses in HIV-positive children indicate a high incidence of viral, fungal and bacterial infections of the skin, compared with HIV-negative children. The skin is the environment in which a diverse community of microorganisms (microbiota) lives. The Global Human Microbiome Project proved the uniqueness of the human microbiome, and suggests to study the effect of human immunity on the formation of microbiome diversity models. The purpose of this study was to assess the incidence of S. aureus, S. spp., C. albicans, C. glabrata, C. krusei, C. tropicalis / C. parapsilosis as a part of skin microbiota in HIV-positive children by polymerase chain reaction.

Aim. Confirmation of the efficacy and safety of the drug riamilovir (Triazavirin), 100 mg capsules, in children aged 1217 years with the diagnosis of acute viral respiratory infection (ARVI). Materials and methods. The multicenter study included 269 patients diagnosed with acute viral respiratory infection (ICD-10 code: J00, J02, J02.9, J04, J04.0, J04.1, J04.2, J06, J06.0, J06.9) in the presence of clinical manifestations and confirmation of the etiology of the disease by laboratory tests (PCR method). Patients were included in the study after one of the patient's parents/adoptive parents and the patient signed an informed consent to participate in the study. The interval between the appearance of the first symptoms of the disease and the inclusion of the patient in the study did not exceed 36 hours. Results. As a result of a clinical study, the efficacy and safety of treatment with riamilovir (Triazavirin) in sick children aged 1217 years with a diagnosis of ARVI was shown. A decrease in the duration of the disease was shown when using the drug riamilovir (Triazavirin) compared with the control group. No serious adverse events were detected during the study. Conclusion. As a result of the conducted clinical study, the high efficacy, safety and good tolerability of the drug riamilovir in the treatment of children aged 1217 years with a diagnosis of ARVI was established. It is recommended to use the drug riamilovir in clinical practice as an etiotropic therapy in children aged 1217 years with a diagnosis of ARVI due to its high efficacy and safety.