Background: This study aimed to examine the effectiveness of Remdesivir in reducing Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) viral load and its safety for antiviral therapy in Coronavirus disease 2019 (COVID-19) treatment.Methods: This systematic review used data sources from the PubMed, ProQuest, SpringerLink, and ClinicalTrial.gov databases for relevant observational and interventional studies during August 2020 to August 2021. Studies evaluating Remdesivir in adults hospitalized for COVID-19 were included in this review. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines.Results This review found 9 studies that were relevant to the study objectives. In total, 1,088 patients participated as subjects. Three studies demonstrated the effect of remdesivir in reducing SARS-CoV-2 viral load in upper and lower respiratory tract specimens. Six studies demonstrated that remdesivir was safe for use in a variety of baseline conditions (patients on hemodialysis and patients receiving kidney transplantation), had no significant hepatotoxicity, did not increase the risk of acute kidney injury, and did not increase eGFR or systemic symptoms in patients taking remdesivir.Conclusion: Remdesivir has been shown to reduce SARS-CoV-2 viral load and was safe for use as antiviral therapy in the treatment of COVID-19, but an assessment of randomized controlled trial for the effect of Remdesivir on viral load reduction was not available yet.

The Covid-19 pandemic which has been afflicting Indonesians since the beginning of 2020 has a tremendous influence on their lives in variety of ways. The Indonesian government has taken steps to ensure that citizens are protected and that the number of positives is reduced. Keeping the rights of people seeking justice to continue litigating during the Covid-19 pandemic while simultaneously guaranteeing the safety of those infected with the virus is problematic in the field of law enforcement and justice during the Covid-19 epidemic. As a result, the government through the Supreme Court of Indonesia used the Salus Populi Suprema Lex Esto principle which means that people's safety is the highest law by passively using technology in litigation and increasing the supporting facilities for strict health protocols throughout the judiciary, including the Sungguminasa Religious Court. In the context of Maqashid Syariah, the goal of this study was to show and explain the harmony of the use of the Salus Populu Suprema Lex Esto Principle during the Covid-19 Pandemic. This study took a qualitative and empirical approach. The study of primary data source was interviews conducted by judges and court personnel. Collecting, decreasing, presenting, and describing results were all part of the data analysis process. The findings of the investigation revealed that during the Covid-19 epidemic, the government's efforts to uphold justice while preserving the safety of the human soul, such as Maqashid Syariah's of the hifz an-nafs, which is at the primary level was dharuriyyah