The problem of treating patients with malignant neoplasms of the extrahepatic bile ducts and the large duodenal papilla remains relevant due to the growing incidence, high mortality, and a pronounced decrease in the quality of life of patients, despite the radical surgery. The purpose of this study was to evaluate the effectiveness of photodynamic therapy (PDT) in inoperable patients with malignant tumors of these localizations.The study is based on the treatment of 79 patients with adenocarcinoma of large duodenal papilla and extrahepatic bile ducts. 29 patients received palliative bile drainage operations with PDT. 50 patients in the control group only had palliative bile drainage operations. Patients in the study group received from 1 to 3 PDT courses in a year. In total, 29 patients received 52 PDT courses. The tolerance to the method and the life expectancy of patients were evaluated. The median survival of patients who underwent PDT was 18 months (11–60 months); in the control group – 11.5 months. PDT, in combination with bile drainage operation, is an effective method for the treatment of inoperable patients with malignant neoplasms of the extrahepatic bile ducts and the large duodenal papilla in the absence of severe complications and with easy tolerance to therapy by patients. For the treatment and prolongation of life of patients whose radical surgical treatment is associated with a high risk of death, PDT seems to be the best treatment option. Results of PDT treatment for cancer of this localization are comparable with the results of radical surgeries and exceed those for palliative surgeries.

No abstract

No abstract

Purpose: to assess the effectiveness of carbon dioxide laser light in the treatment of benign skin neoplasms.Material and methods. The researchers have analyzed outcomes in 1394 patients treated for benign skin neoplasms. In the main group (n = 1184), laser photocoagulation (vaporization) and laser photohydraulic preparation were applied. Laser surgical devices “Lancet-1” and “Lancet-2” in continuous and pulsed modes, power up to 20 W, focused beam up to 1 mm were used. In the control group (n = 210), traditional techniques (excision and electrocoagulation) were applied.Results. High effi ciency of CO2 laser light for the removal of benign skin neoplasms has been confi rmed. Such a technique has a minimal rate of complications and relapses and satisfactory aesthetic outcomes, compared to the conventional treatment.Conclusion. Carbon dioxide laser light is highly effective for treating benign skin neoplasms.