The scale of individual prognosis in patients PHC takes into account both clinical and histopathological tumor characteristics. This scale may be useful to optimize the individual treatment.

Ключевые слова: опухоль Клатскина, факторы риска, классификация, диагностика, лечение, прогноз. Klatskin tumorarises from the common hepatic duct and its bifurcation the bile ducts and is the most common primary malignancy of the biliary tree. The location of the tumor and its close relationship with vascular structures at the hepatic hilum have resulted in a low resectability and high rate morbidity and mortality. Improvementof instrumental diagnostics and operative techniquesallowsto performextendedresectionand complexinterventions onthe liver, bile ductsand vascularstructuresat the hepatic hilum. The role ofchemoradiotherapyandphotodynamic therapyis not fullyunderstood. Thus, questions of treatmentandprognosis of the diseaseare remain relevantandrequire further study.

To show the need for a comprehensive assessment of non-invasive, invasive and laboratory examination of patients with newly diagnosed hepatitis, especially in presence of space-occupying lesions of the liver (cysts) for detection of cancer pathology. Methods of performing. To confirm the diagnosis of HCC, the following instrumental methods of examination of the patient have been performed: ultrasound, CT and MRI of the internal organs of the pelvis and abdomen. The puncture of cystic formation was performed with the purpose of morphological verification of the diagnosis. A morphological and histological study of the tumor was performed. Evaluation of laboratory parameters included the basic general clinical and biochemical analyzes, as well as FibroMax, tumor markers: CEA, SA19-9, AFR, the qualitative and quantitative determination of HCV RNA. Results. Showed that taken separately laboratory values or single screening tool examination fail to give the fully valid answer about the nature and course of the pathological process. Conclusion. Comprehensive evaluation of patients with newly diagnosed HCV and timely initiated antiviral therapy permit to prevent or postpone the promote manifestations of chronic HCV, to preclude the development of primary HCC and its recurrence. When making a decision on the tactics of the management of the patient it is necessary to consider the totality of all the necessary instrumental and non-instrumental and laboratory methods of examination Keywords: chronic viral hepatitises C, hepatocellular carcinoma, oncomarkers, treatment of HCC and CHCV

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