Aim. Comprehensive epidemiological assessment of factors affecting the effectiveness of the infertility treatment in medical organizations of St. Petersburg. Materials and Methods. The effectiveness of assisted reproductive technology programs in St. Petersburg reproductive centers was evaluated by analyzing the respective database for infertility treatment in 2013-2017. We retrospectively examined 843 patient records that were submitted to one of the St. Petersburg reproductive centers in 2014-2017 with the following survey and in-depth clinical examination of 129 couples before in vitro fertilisation. Results. Risk factors of infertility included vaginal dysbiosis (OR = 7.5 (95% CI 1.04-54.1)), Trichomonas vaginalis infection (OR= 2.6 (95% For citation:

Introduction. One of the key factors influencing on the quality of drinking water is the high level of water sources of the pollution, leading to the need for large-scale water treatment. There are remained risks, the consequence of which may lead to the deterioration of the quality of drinking water which is conveyed to the population. It is necessary to introduce effective technologies of water treatment, informative and reliable approaches for the assessment of epidemiological safety and harmlessness of drinking water. One of the priority directions is the development and use of methods of the integral assessment of drinking water quality. Aim of the study. For this purpose there was developed a method for the integral assessment of drinking water relying upon indices of the chemical harmlessness and a method for the comprehensive assessment of the risk of bacterial intestinal infections transmitted by water. There is proposed a method of assessing the quality of drinking water in terms of epidemiological safety, based on the fundamental principles, and providing a probabilistic approach to the assessment of health risk. Conclusion. The development, argumentation and implementation of the method of the integral assessment of the probabilistic health risk with the combined effect of chemical and microbiological agents contained in drinking water remain to be actual.

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Purpose of the study. The investigation of the character of the formation of statistical presentation of data about ambient air pollution within the borders of Saint-Petersburg administrative areas on the basis of simulation data of hazardous substances (air emissions) transfer from priority sources into the lowest atmospheric layer with their following assessment according to standards, population health risks and reliability of index estimation, averaged on borders of administrative areas. Material and methods. On the base of data of sources of pollution of ambient air of the city of Saint Petersburg administered by the Committee for the use of Natural Resources, Environmental Protection and Safety Calculations, implemented in the system “Ecologist-city” by the company “Integral” there were made calculations maximum one-time and annual average concentrations for all emitted substances as well as there were evaluated the carcinogenic, non-carcinogenic and chronic risks air pollution, and there was executed the assessment of the pollution according to olfactometric criteria (rate of exceeding odor threshold ). The spatial analysis of the results was concluded in averaging concentrations and values which characterize risks on the borders of the administrative areas and further performance of the estimation of the reliability of data differences of average indices on Student criteria. Results. There were investigated peculiarities of air pollution within the borders of St. Petersburg administrative areas. There was given the estimation of reliability of data differences by Student criteria for carcinogenic, non-carcinogenic (acute and chronic) risks. There were selected priority substances, which had the greatest differences in values of concentrations and risk criteria. They are nitrogen dioxide, nitrogen oxide, sulphur dioxide and benzene. There were determined areas which have statistically reliable differences on olfactometric criteria, the value of annual average and maximum one-time concentrations, by carcinogenic and non-carcinogenic (acute and chronic) risks with other areas. Conclusion. There was established the expediency of calculated monitoring of the air pollution averaged on the administrative areas.

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