The study of the immune status markers and characteristics of genetic polymorphism in potash mining workers under the impact of combined industrial factors was performed. We showed the inhibition ofphagocytosis and production of serum IgG and IgM, the deficiency of mediators of the immune and endothelial regulation of interleukin-17, VEGF, GAD1 and GAS6. The revealed changes are associated with the negative genetic fixation of key polymorphisms responsible as well for the detoxification of the first and second phase of the neuro-immune regulation, the state of the vascular endothelium and apoptosis, as both due to heterozygous and due to the homozygous variant genotypes of genes of cytochrome (CYP1A1), Sulfotransferase (SULT1A1), toll-like receptor (TLR4), tumor necrosis factor (TNF), endothelial growth factor (VEGFA)