The S N R 8 supersymmetric orbifold sigma model is expected to describe the IR limit of the Matrix string theory. In the framework of the model the type IIA string interaction is governed by a vertex which was recently proposed by R.Dijkgraaf, E.Verlinde and H.Verlinde. By using this interaction vertex we derive all four particle scattering amplitudes directly from the orbifold model in the large N

Introduction. Non-neurogenic lower urinary tract symptoms (LUTS) are a serious polyetiologic problem in the male population. The side effects of the medication agents used to treat LUTS significantly reduce treatment compliance. According to the literature data, the frequency of refusal for the proposed treatment during the year varies from 20 to 80%. Several studies have shown the benefits of herbal medicine for LUTS concerning the fewer side effects and increased adherence to treatment. However, to obtain a high-level recommendation base, clinical trials are required.Purpose of the study. To evaluate the effectiveness of Gardaprost® in LUTS combination therapy.Materials and methods. The study included 57 men aged 60 – 70 years with diagnosed medium- or large-volume benign prostatic hyperplasia (BPH) and moderate-to-severe LUTS according to I-PSS, morphologically excluded prostate cancer, without urinary infection signs. The patients were randomized into two follow-up groups. Tamsulosin 0.4 mg q.d. was prescribed to patients in the control group. Patients of the main group received Gardaprost® 0.4 mg q.d. in addition to Tamsulosin. The follow-up period in both groups was one-year. The statistical analysis includes data from 56 men. To evaluate therapy at the screening visit and on days 180 and 360, I-PSS, urination diary, IIEF-5, urinalysis, prostate-specific antigen, uroflowmetry, ultrasound were analyzed. Paired t-test and one-way ANOVA test were used to determine intergroup differences in normally distributed variables. For variables with a distribution other than normal, Friedman's two-way ANOVA for related samples was used. Events with a probability greater than 95% were considered statistically significant.Results. At the time of inclusion in the study, the groups were comparable concerning the control parameters. In the main group, there was a more pronounced positive dynamics in the I-PSS score, maximum urine flow rate, and post-void residual urine volume, which corresponded to 7.9 ± 2.1 points, 18.0 ± 7.3 ml/sec, 23.6 ± 13.6 ml vs 19.7 ± 7.2 points, 10 ± 3.5 ml/sec, 65.9 ± 33.2 ml in the main and control groups, respectively (p < 0.001). Additionally, in the main observation group, a decrease in prostate volume was recorded by 18.8% (p < 0.001) was recorded.Conclusion. We have obtained encouraging long-term results from the use of Gardaprost® in combination therapy of moderate-to-severe LUTS caused by medium- and large-volume BPH.

Введение. Этиология и патогенез симптомов нарушенного мочеиспускания и эректильной дисфункции в полной мере не ясны при метаболическом синдроме. Цель исследования. Определить роль метаболического синдрома в развитии и течении дизурии и эректильной дисфункции. Материалы и методы. В исследовании принимали участие 115 мужчин в возрасте 40-60 лет. Пациенты разделены на две группы на основании наличия или отсутствия доказанного метаболического синдрома. Возраст пациентов в основной группе (n = 86) составил 52,0 ± 3,5 года. Контрольная группа (n = 29)-мужчины без метаболического синдрома в возрасте 50,5 ± 2,4 года. Пациентам проводили анкетирование по опросникам IPSS (Международная система суммарной оценки заболеваний предстательной железы), МИЭФ-5 (Международный индекс эректильной функции). Выполнено объективное (физикальное) обследование. Лабораторная диагностика включала определение следующих показателей: тестостерона общего, альбумина, ГСПГ (глобулина, связывающего половые гормоны), уровня свободного тестостерона рассчитывали на основании трёх предыдущих показателей, ЛГ (лютеинизирующего гормона), инсулина, глюкозы, гликозилированного гемоглобина, липидного профиля. Всем пациентам выполнены урофлоуметрия, УЗИ (ультразвуковое исследование) мочевого пузыря с определением объёма остаточной мочи, ТРУЗИ (трансректальное ультразвуковое исследование) простаты с доплеровским исследованием кровотока. Достоверность различий определяли непараметрическим критерием Манна-Уитни, статистически значимыми считали различия при вероятности больше 95%. Результаты. Пациенты с метаболическим синдромом имели статистически достоверно более выраженную симптоматику по шкале IPSS и более низкий индекс QoL. По данным урофлоуметрии, показатели максимального потока в основной группе наблюдения были достоверно ниже при увеличении длительности мочеиспускания. Пациенты с метаболическим синдромом предъявляли более выраженные жалобы на эректильную дисфункцию по шкале IIEF5 в сравнении с контрольной группой наблюдения. Полученные данные позволяют связать метаболический синдром с риском развития симптомов нарушенного мочеиспускания и эректильной дисфункции у мужчин. Заключение. Метаболический синдром выступает независимым фактором эректильной дисфункции и гипогонадизма, что ведёт к нарушениям микции. Ключевые слова: метаболический синдром; дизурия; эректильная дисфункция; симптомы нижних мочевых путей Финансирование. Исследование не имело спонсорской поддержки. Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. Информированное согласие. Все пациенты подписали информированное согласие на участие в исследовании. Вклад авторов: Сергей В. Шкодкин-подготовка и написание статьи; Алексей В. Полищук-получение, анализ и статистическая обработка первичных данных исследования; Сергей В. Чирков-получение первичных данных; Абдуллои Ф. Хусейнзода-получение первичных данных; Мохаммедейн З. Абед Альфаттах Зубаиди-получение первичных данных.

Introduction. The problem of effective and safe therapy of patients with benign prostatic hyperplasia and prostatitis of category III remains relevant, despite the numerosity of the drugs used in different groups. Under these conditions, the search for new pharmacological agents continues.The study objective was to evaluate the efficacy of Adenoprosin in the treatment of lower urinary tract symptoms and erectile dysfunction in patients with chronic pelvic pain syndrome and prostate hyperplasia.Materials and methods. The 90-day study included 60 patients aged 40 to 60 years with chronic pelvic pain syndrome and erectile dysfunction on the background of benign prostatic hyperplasia. Patients of the main group received alfa-1-adrenoreceptor blocker tamsulosin for 30 days in combination with the nonsteroidal anti-inflammatory drug nimesulide for 5 days and Adenoprosin suppositories. The men of the control group took tamsulosin for 30 days and nimesulide for 5 days. Over the next 60 days, the dynamics was evaluated based on the data from the NIH-CPSI (National Institutes Health Chronic Prostatitis Symptom Index), IPSS (International Prostate Symptom Score), QoL (Quality of Life Scale), AMS (Aging Male Symptoms), IIEF-5 (International Index of Erectile Function); urination diary analysis; general urine analysis; blood test for the level of prostate specific antigen, glucose; prostate secretion analysis; transrectal ultrasound examination of the prostate gland with measurement of residual urine; uroflowmetry.Results. Urinary frequency decreased at day 30 in the treatment group from 12.7 ± 1.4 to 7.3 ± 1.8 micturitions per day, in the control group from 13.1 ± 1.8 to 9.6 ± 1.1; subsequently (on days 60 and 90) positive effect persisted in the treatment group, while in the control group urinary frequency increased. Per the NIH-CPSI questionnaire, symptoms decreased at day 30: in the treatment group from 25.4 ± 2.1 to 12.3 ± 1.9 points, in the control group from 24.3 ± 1.7 to 17.6 ± 0.4 points; in the treatment group the trend towards symptom decrease remained, while in the control group symptoms increased at day 90. IPSS score at day 30 decreased in the treatment group from 12.9 ± 0.5 to 5.2 ± 1.4, in the control group from 14.1 ± 0.7 to 8.2 ± 0.9; further decrease was observed in both groups at day 60, but at day 90 the score increased (higher in the control group). Quality of life (QoL) improved in both groups at day 30 (in the treatment group 1.4 ± 0.6 points, in the control group 3.1 ± 0.8). Erectile function improved per the IIEF-5 questionnaire: in the treatment group from 11.5 ± 1.1 to 18.9 ± 1.4 points at day 30 with further positive tendency, in the control group from 10.7 ± 1.4 to 15.3 ± 1.1 points with subsequent negative dynamics. Uroflowmetry showed positive dynamics of Q max at the end of treatment in the treatment (from 8.3 ± 1.5 to 14.7 ± 1.1 mL/s) and control (from 8.8 ± 1.3 to 13.1 ± 1.6 mL/s) groups, with its further decrease. Prostate volume in the treatment group was about 33.5 ± 3.1 cm3 at day 90 (with baseline volume 42.6 ± 2.5 cm3), in the control group it was 41.6 ± 1.9 cm3 (with baseline volume of 43.1±1.4 cm3). No significant changes in urine tests, prostatic fluid, prostate-specific antigen level, and blood glucose were observed during the treatment.Conclusions. The study shows that administration of tamsulosin with Adenoprosin in patients with BPH and category III prostatitis is advantageous compared to administration of only alfa-1-adrenoreceptor blockers.

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