Magnetic nanocomposites based on polyaniline (PANI) and magnetite nanoparticles (Fe 3 O 4 NPs) have been prepared by an in situ self-assembly method in presence of dodecylbenzene sulfonic acid (DBSA) as dopant as well as surfactant. Influence of the aniline to DBSA molar ratio on morphology, magnetic properties, and thermal stability of PANI/Fe 3 O 4 NPs composites has been investigated. Spectroscopic results indicated the interaction between PANI nanorods and Fe 3 O 4 NPs. Scanning electron microscopy and transmission electron microscopy images indicated that PANI rods were decorated with Fe 3 O 4 NPs. Morphologies of nanocomposites were found to be critically dependent on molar ratios of organic acid to monomer. PANI nanorod/Fe 3 O 4 NPs composites showed superparamagnetism and higher thermal stability with small mass fraction of Fe 3 O 4 NPs.

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A sensitive, selective rapid bioanalytical assay method was developed and quantification of iloperidone (ILP) and olanzapine (OLZ) in rat plasma was done by mass spectrometry. Systematic sample preparation and extraction procedure were carried out by supported liquid extraction using dichloromethane to extract both the eluents (ILP and OLZ) from rat plasma samples. The extorted samples were injected on a selective Waters XTerra® C18 reverse-phase bonded column (250 × 4.6 mm i.d., 5 μm) using acetonitrile and 15 mM ammonium formate containing 0.05% trifluoroacetic acid (60:40 v/v) for isocratic elution mode and detected by mass spectrometry. Calibration curves were drawn with the respective assay statistical data and showed linear regression coefficients greater than 0.9996 over the concentration ranges 2-5,000 ng/mL for ILP and OLZ, respectively. The absolute mean recoveries were found to be in the replicate range of 87.12-94.47%, respectively. The obtained results by the method revealed good intra and interday assay performance in terms of 1.70-5.90% precision and 0-5% accuracy. The validated bioassay method has been successfully applied to the pharmacokinetics in rats.

In this work, polyaniline (PANI) nanorods and magnetite (Fe 3 O 4 ) nanoparticles have been synthesised by using ammonium persulphate as oxidant via in-situ chemical oxidative polymerisation of aniline in presence of excess of organic sulphonic acid. The resulting PANI/Fe 3 O 4 nanocomposites materials were characterised using X-ray diffraction, UV-visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, vibrating sampling magnetometer and thermogravimetric analysis. Spectroscopic results indicated the successful formation of PANI/Fe 3 O 4 nanocomposites. As obtained, PANI/ Fe 3 O 4 nanocomposites have Fe 3 O 4 particle size in the range of 3.2-7 nm. Morphologies of PANI/ Fe 3 O 4 nanocomposites were found to be dependent on the molar ratio of aniline to organic acid. Under certain polymerisation conditions, PANI rods like structures were obtained. PANI/Fe 3 O 4 nanocomposites have superparamagnetism and higher thermal stability.