N {2 [(1 R Cyclopropyl)methyl]prop 2 enyl} N,N dimethylamines were prepared in 80-90% yields by the reaction (5 h, 23-25°C) of propargylamines R-C≡C-CH 2 NMe 2 (where R = alkyl, Ph) with a system of reactants CH 2 I 2 -Et 3 Al taken in the molar ratio [propargylamine] : [Et 3 Al] : [CH 2 I 2 ] = 1 : 6 : 6. In the case of phenyl substituted propargyl amine, N ({1 [(1 phenylcyclopropyl)methyl]cyclopropyl}methyl) N,N dimethylamine is selectively formed in 76% yield upon the elongation of the reaction time to 4 days.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.