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ObjectivesPolypharmacy is commonly defined as the use of five or more medications, is associated with a range of adverse outcomes and is particularly common in older adults. We sought to examine the relationship between polypharmacy and payment methods for prescription drugs among older adults in Ireland.MethodsThis is a cross-sectional analysis of data from wave 3 of The Irish Longitudinal Study on Aging, a nationally representative cohort study sample of community-living adults aged 50 years and older in Ireland. We used multivariable logistic regression to model the independent relationship between polypharmacy and drug payment methods. We controlled for a wide range of demographic, socioeconomic and health-related variables.ResultsEnrolment in publicly funded schemes which entitle participants to subsidised or free prescription medications was independently associated with increased odds of reporting polypharmacy. Relative to out-of-pocket payment, we found polypharmacy was independently associated with payment via medical card (OR 2.65; 95% CI 2.13 to 3.28), drugs payment scheme (OR 3.83; 95% CI 2.96 to 4.95), long-term illness scheme (OR 4.24; 95% CI 3.06 to 5.87), but not private health insurance (OR 0.82; 95% CI 0.42 to 1.62).ConclusionsGiven multiple payment methods available for funding prescription charges in Ireland, there is a significant differential in the upfront costs faced by patients. One implication of our results is that the quantity of medications consumed by an individual may be influenced by payment methods for prescription fees. This could lead to overconsumption of medicines by those who are covered, or underconsumption by those who are not. However, our study was limited by an inability to discriminate between appropriate and inappropriate polypharmacy or to account for differential levels of multimorbidity, suggesting further research on this topic is warranted.

were identified with 90% from West Europe. HB-HTA reports were mainly prepared by academic centres (65%) followed by governmental organisations (18%) and less than 10% of the reports by hospital networks. Therapeutic procedures were most commonly evaluated (93%) with drugs constituting 76% of all reports. Clinical analyses were provided by 71% of reports while 68% and 34% reports included economic evaluations and budget impact analyses, respectively. Majority of decisions were positive or conditionally positive (20 and 32%, respectively), however almost 1/3 of reports were nonconclusive. Conclusions: HB-HTA is an established approach in decision making practice and needs an effective implementation to facilitate faster and more tailored uptake of technologies.

We present a case report of position-dependent tachyarrhythmia following prone positioning for surgery in a 42-yr-old female with a left-sided totally implantable venous access system (TIVAS) in-situ. TIVASs are becoming increasingly popular for cancer patients receiving chemotherapy and who may present for either elective or emergency surgery.

Background and ObjectiveIn Ireland, similar to other jurisdictions, health technology assessment (HTA) is used to inform the health payer's drug reimbursement decisions. These HTAs are conducted by the National Centre for Pharmacoeconomics (NCPE). In 2009, the NCPE introduced the Rapid Review process to identify drugs that do not require further assessment in the form of the previously established full HTA process. Methods A retrospective analysis of all Rapid Reviews submitted to the NCPE from 2010 to 2019, inclusive, was conducted. Rapid Review recommendation was recorded (i.e. full HTA required or not required). For those submitted from 2012 to 2019, additional data relating to the drug, economic and clinical evidence-related factors were collected. Multivariable logistic regression methods were used to model the relationship between these factors and the likelihood of requiring a full HTA. An exploratory analysis estimated the additional NCPE appraisal time that would have been required to evaluate all drugs, had the Rapid Review process not been established. Results Of the 446 Rapid Reviews submitted, approximately half (49.6%) were deemed to require a full HTA. Drugs for cancer indications, drugs designated first-in-class status, and high-cost drugs were positively and significantly associated with the likelihood of requiring a full HTA. No significant association was found for drugs for orphan indications when factors relating to cost and clinical evidence were included in the model. Without the Rapid Review process, an estimated additional 15,631 NCPE appraisal days would have been required to evaluate all drugs submitted over the 10-year period. Conclusions This is the first study to use data uniquely available to the NCPE to evaluate factors associated with the requirement for a full HTA following a Rapid Review. The process has reduced the NCPE appraisal time required to evaluate all submissions over the study period. The NCPE's Rapid Review process allows for appropriate resource prioritisation within a national HTA agency.