Methods: Markers of INF, OS, antioxidant enzymes SOD and GSH-PX were measured in 66 patients with CKD (stage 1 to 5) and in 50 controls; Glomerular filtration (eGFR)calculated by MDRD or CKD-EPI formula. Serum creatinine(sCr), C reactive protein(CRP), interleukin-6(IL-6), MDA(malondialdehyde), SOD and GSH-PX were measured again after 9 months follow-up. Results: CRP, IL-6 and MDA significantly increased, and SOD and GSH-PX -decreased with development of CRF. GFR was inversely associated with MDA(P<0.05), and positively with SOD and GSH-PX (P < 0.02); (p<0.05). IL-6 and CRP were positively correlated with MDA(P < 0.01);(P<0.005) and negatively associated with SOD and GSH-PX (p < 0.05); (P<0.01).