Wendelstein 7-AS was the first modular stellarator device to test some basic elements of stellarator optimization: a reduced Shafranov shift and improved stability properties resulted in β-values up to 3.4% (at 0.9 T). This operational limit was determined by power balance and impurity radiation without noticeable degradation of stability or a violent collapse. The partial reduction of neoclassical transport could be verified in agreement with calculations indicating the feasibility of the concept of drift optimization. A full neoclassical optimization, in particular a minimization of the bootstrap current was beyond the scope of this project. A variety of non-ohmic heating and current drive scenarios by ICRH, NBI and in particular, ECRH were tested and compared

Demonstrating improved confinement of energetic ions is one of the key goals of the Wendelstein 7-X (W7-X) stellarator. In the past campaigns, measuring confined fast ions has proven to be challenging. Future deuterium campaigns would open up the option of using fusion-produced neutrons to indirectly observe confined fast ions. There are two neutron populations: 2.45 MeV neutrons from thermonuclear and beam-target fusion, and 14.1 MeV neutrons from DT reactions between tritium fusion products and bulk deuterium. The 14.1 MeV neutron signal can be measured using a scintillating fiber neutron detector, whereas the overall neutron rate is monitored by common radiation safety detectors, for instance fission chambers. The fusion rates are dependent on the slowing-down distribution of the deuterium and tritium ions, which in turn depend on the magnetic configuration via fast ion orbits. In this work, we investigate the effect of magnetic configuration on neutron production rates in W7-X. The neutral beam injection, beam and triton slowing-down distributions, and the fusion reactivity are simulated with the ASCOT suite of codes. The results indicate that the magnetic configuration has only a small effect on the production of 2.45 MeV neutrons from DD fusion and, particularly, on the 14.1 MeV neutron production rates. Despite triton losses of up to 50 %, the amount of 14.1 MeV neutrons produced might be sufficient for a time-resolved detection using a scintillating fiber detector, although only in high-performance discharges.

The reversible protein phosphorylation on serine or threonine residues that precede proline (pSer/Thr-Pro) is a key signaling mechanism for the control of various cellular processes, including cell division. The pSer/Thr-Pro moiety in peptides exists in the two completely distinct cis and trans conformations whose conversion is catalyzed specifically by the essential prolyl isomerase Pin1. Previous results suggest that Pin1 might regulate the conformation and dephosphorylation of its substrates. However, it is not known whether phosphorylation-dependent prolyl isomerization occurs in a native protein and/or affects dephosphorylation of pSer/Thr-Pro motifs. Here we show that the major Pro-directed phosphatase PP2A is conformation-specific and effectively dephosphorylates only the trans pSer/Thr-Pro isomer. Furthermore, Pin1 catalyzes prolyl isomerization of specific pSer/Thr-Pro motifs both in Cdc25C and tau to facilitate their dephosphorylation by PP2A. Moreover, Pin1 and PP2A show reciprocal genetic interactions, and prolyl isomerase activity of Pin1 is essential for cell division in vivo. Thus, phosphorylation-specific prolyl isomerization catalyzed by Pin1 is a novel mechanism essential for regulating dephosphorylation of certain pSer/Thr-Pro motifs.

After completing the main construction phase of Wendelstein 7-X (W7-X) and successfully commissioning the device, first plasma operation started at the end of 2015. Integral commissioning of plasma start-up and operation using electron cyclotron resonance heating (ECRH) and an extensive set of plasma diagnostics have been completed, allowing initial physics studies during the first operational campaign. Both in helium and hydrogen, plasma breakdown was easily achieved. Gaining experience with plasma vessel conditioning, discharge lengths could be extended gradually. Eventually, discharges lasted up to 6 s, reaching an injected energy of 4 MJ, which is twice the limit originally agreed for the limiter configuration employed during the first operational campaign. At power levels of 4 MW central electron densities reached 3  ×  1019 m−3, central electron temperatures reached values of 7 keV and ion temperatures reached just above 2 keV. Important physics studies during this first operational phase include a first assessment of power balance and energy confinement, ECRH power deposition experiments, 2nd harmonic O-mode ECRH using multi-pass absorption, and current drive experiments using electron cyclotron current drive. As in many plasma discharges the electron temperature exceeds the ion temperature significantly, these plasmas are governed by core electron root confinement showing a strong positive electric field in the plasma centre.