Summary. The aim of the study. To study the pathomorphological changes in adhesion formation, and to determine the main critical moments of adhesiogenesis in adhesion disease due to acute inflammatory injuty to the peritoneum. Materials and methods. The study included 28 cases of adhesion formation in operated patients (average age — 27.91±4.61 yrs). The material was collected intraoperatively in accordance with standard requirements for the production of histological preparations. To obtain differentiated polychromy of tissues, staining of micropreparations with hematoxylin-eosin and the van Gieson method were used. Results and their discussion. The histological picture varied from immature granulation tissue to signs of degenerative changes in the tissue of the formed adhesions. In some cases, the development of the adhesion process acquired features of combined fibrous and fatty degeneration. The obtained data showed a clear phasic development of adhesiogenesis from the inflammatory process to the formation of powerful connective tissue structures with the phenomena of hyalinosis and secondary degenerative changes. Conclusions. The study of the patterns of formation of the adhesion process showed that adhesion disease is characterized by a certain phasic development of changes from alternative damage and non-specific inflammation to the formation of sufficiently differentiated connective tissue and changes of a secondary degenerative nature. The obtained data create prerequisites for the development of methods of influence (prevention) at each stage of the development of adhesion disease and adhesiogenesis.

Summary. Introduction. Abdominal sepsis (AS) is the most serious complication of inflammatory processes in the abdominal cavity, characterized by high mortality and morbidity. Violation of hemostasis is one of the key components of the pathogenesis of sepsis. Goal. Establishing the pattern of violations in the system of thrombocyte-vascular hemostasis in patients with abdominal sepsis in the postoperative period, as a prerequisite for the occurrence of adhesions. Materials and methods. The study covers observation of 52 patients with various forms of AS, aged 18-69 years (41.93±3.47). The control group consisted of 17 patients who underwent planned surgical interventions not related to the peritoneal cavity. The dynamics of the content of soluble fibrin-monomer complexes, prostacyclin and thromboxane were determined by the content of their stable metabolites in the blood. Results and discussion. Probable correlative dependences between the content of fibrin-monomer complexes in the blood and the concentration of TxB2 (positive correlation) and the level of prostacyclin in the blood plasma (negative relationship) were revealed. Identified violations in the system of primary hemostasis in patients with AS indicate the need for active correction of changes in thromboxane-prostacyclin systems in order to prevent thrombotic postoperative complications of a septic nature. Conclusions. Identified violations in the system of primary hemostasis in AS already on the first day after surgery indicate the need for active correction of changes in thromboxane-prostacyclin systems in order to prevent thrombotic postoperative complications of a septic nature. Taking into account the high risk of adhesion formation due to inflammatory processes of the peritoneum, it is advisable to consider the identified violations of primary hemostasis as a factor in the pathogenesis of adhesion disease.