Simulations of human disease in laboratory animals have continuously accompanied the history of medical discoveries and have helped researchers obtain useful information in medicine. The separation of physiological processes into their constituent components through modeling is one of the important parts of any research. Wound healing is a complex process. Using of models (in vitro, in vivo - on animals and humans) allowed large-scale research in this area, which significantly improved the knowledge of the healing mechanisms of both acute and chronic skin wounds. In parallel with the knowledge gained, the development of new wound treatments continues and the understanding of how to improve their care for the best results continues. Although in vitro and animal models have a place in these studies, by far the best models are those that rely on volunteers and provide physiologically more accurate mechanisms of skin pathogenesis and healing.