AAV VECTORS IIwhich increased the transduction effi ciency approximately ten-fold compared with the wild-type (WT) AAV2 vector. Combining the best performing S662V mutant with T491V further enhanced the transduction effi ciency by approximately 8-fold. Taken together, these data suggest that high-effi ciency transduction of moDCs by capsid-modifi ed AAV vectors is indeed feasible, which supports the potential utility of these vectors for future human DC vaccine studies.

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