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virtually the same style as Index Medicus for reference lists (apart from the position of the date) this method would do away with the need for articles rejected by one journal to be retyped before submission to a similar journal favouring a different reference system. The method has the extra advantage of reducing the possibility of wrong numbers creeping inauthors using numbered references have been discovered apparently citing with approval papers that in fact contradict their own line of argument! We would ask the Vancouver group to consider adopting this ELSE-Ciba Foundation suggestion next time the otherwise admirable Uniform Requirements come up for revision.

reassurance did not change participants initial impressions of acceptability. Conclusion Conducting a human challenge study in pregnancy would be acceptable to some pregnant women and may offer a means to investigate the specific environment that surrounds commensalisation of neonates. Furthermore, this may offer new avenues to explore vaccine development for the prevention of neonatal infection. While participants would want the maximum amount of information available before considering whether to participate, initial aversion to this methodology it is unlikely to be changed.