A case of involvement of the pituitary gland in Wegener's granulomatosis in a patient with diabetes inspidus and hyperprolactinemia is presented. Initial magnetic resonance imaging (MRI) revealed loss of normal high signal in the posterior pituitary on T1-weighted images (T1WI) while the anterior pituitary was enlarged showing a central low signal intensity area on T1WI and high signal intensity on T2WI. Repeated MRI after treatment showed almost complete radiological resolution of these abnormalities along with clinical improvement.

Introduction: About 3-8% of fractures are missed in the adult emergency department (ED). No study has examined this in a pediatric ED. Such data is essential to quality improvement. We sought to determine the proportion of missed fractures on x-rays in a pediatric ED, the location of missed fractures and associated factors, and if missed fractures were clinically significant. Methods: We did a retrospective cohort study from Jan 1 to Dec 31, 2013 of 1000 pediatric patients with a fracture on x-ray in our academic pediatric ED. We randomly reviewed radiologist reports to find new fractures. A fracture was missed if identified by the radiologist but not the ED physician. Data was collected on patient, fracture, department and physician characteristics and change in management or complications. Descriptive statistics were used for clinical characteristics. The proportion of missed fractures was computed using the Wilson score method. Factors associated with missed fractures were investigated using chi-squared test. Results: Of 1000 x-rays, 19.4% (95% CI 17.0-22.0%) had at least one fracture missed. However, when possible fractures were removed for further analysis, 13.9% (95% CI 11.7-16.5%) were missed. The bones most associated with missed fractures were pelvis (60%,) carpal (50%,) vertebra (42.9%,) and patella (33.3%) (p<0.001.) However, these accounted for only 12.5% of missed fractures whereas ulna (31.3%,) metatarsal (14.1%,) phalynx of the hand (9.4%,) and fibula (7.8%) accounted for the greatest number of missed fractures. The fracture types most associated with a missed fracture were styloid, Salter-Harris IV, Salter-Harris I, compression, avulsion and buckle (p<0.001.) The presence of multiple fractures was associated with missed fractures (35.0% vs 7.2%, p<0.001) as was older age (11.2 vs 9.5 years, p=0.001). Most missed fractures were not clinically significant (71.9%) but some required splinting or limitation of activities. One had decreased function at 2 months. Conclusion: Overall, the proportion of missed fractures is higher than in adults, stressing difficulties with reading pediatric x-rays. Most missed fractures were not of clinical significance. Carpal, patella, vertebra and pelvis fractures were particularly challenging but were also rare. Ulna, metatarsal, phalynx of the hand and fibula accounted for the greatest number of missed fractures. More education may help improve physician skills in recognizing these fractures.

Objective: To evaluate treatment approaches, role of surgical resection and reconstruction and outcome of patients with primary chest wall tumor. Study Design A prospective observational study. Place and Duration. The study was conducted at the Department of Cardiothoracic Surgery, Postgraduate Medical Institute, Lady Reading Hospital from March 1996 to April 2000. Patient and Methods A total of 39 patients underwent resection for primary chest wall tumors. Male were 27 and female were 12. Age range was 15 years - 55 years with a mean age of 23±2 years. 75% of patients presented with a painless mass while 25% complained of pain. Twenty three were on right side, twelve were on the left side while 4 extended onto the sternum. Sizes were <3cm (7 patients), 3-5cm (24 patients), 5-10cm (6 patients) and > 10cm (2 patients). Chest radiograph in all and CT thorax was done in 20 cases. Out of 39 cases, 25 had previous biopsies attempted by other surgeons leading to ulceration and fungation in 18 cases. Chest wall resection and primary closure was done in 33 cases. In 4 cases marlex mesh alone was used while in 2 cases it was reinforced with Methyl Methacrylate. Results Mean operative time was 68 (+/-40) minutes. Postoperatively, 19 patients required ventilation. Out of these, 14 patients were extubated the same day, 3 the next day while 02 patients died despite prolonged ventilation. Post-operative flail was observed in 3 cases without respiratory compromise. Histopathology reporting were chondrosarcoma in 24, fibrosarcoma in 6 cases while the rest were not reported. Twenty one patients were followed-up for up to one year with no evidence of disease while the remaining were lost to follow up. Conclusion To conclude primary chest wall tumors can be safely managed by resection and primary closure or chest wall reconstruction and are associated with long term survival.

Hydatid disease is a worldwide zoonosis produced by the larval stage of the Echinococcus tapeworm. We demonstrate rare locations and unusual complications of this entity during past 6 years. Rare locations during our observation included lumbar spine, sacral spine, spleen, ovary, abdominal wall, diaphragm, pelvis and right kidney. Unusual complications included formation of bronchopulmonary fistula, complete collapse of left lung secondary to hilar location of Hydatid cyst and hydatiduria.

Objective:: This study seeks to define the clinical presentation, the usefulness of diagnostic tests, surgical management approach and outcome of treatment of diaphragmatic injuries in our trauma patients. Design:: An observational descriptive study. Place and duration of study:: Department of Cardiothoracic Surgery, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar from March 2001 to April 2005. Subjects and methods: In this retrospective study, 50 patients admitted to our department with diaphragmatic injury were evaluated according to the type of injury, diagnostic methods, associated organ injury, treatment, modality, morbidity and mortality. Results: The average age of patients was 32 years. There were 35 (70%) male and 15 (30%0 female patients, 38 (76%) of these patients sustained blunt and 12 (24%) had penetrating chest injury. The diaphragmatic injury was right sided in 4 and left sided in 46 patients. Thirty nine (78%) patients presented in respiratory distress within 48 hours of in jury while 11 (22%) presented with bowel obstructive symptoms months and years after injury. A chest x-ray on admission suggested the diagnosis in 70% of the cases while chest ultrasonography and contrast studies were required in others. Surgery was emergent in 35 (70%), semi-emergent in 9 (18%) and effective in 6 (12%) cases. Surgical approaches were left thoracotomy (40 patients), left thoracolaprotomy (6 patients) and right thoracotomy (4 patients). The diaphragmatic repair was achieved by direct suture in 45 cases while prolene Mesh was required in 5 cases. The mortality rate was 6% (n = 3). Recurrence occurred in one (2%), wound infection in 3 (6%), pleural, space, problem in 1 and chest infection in 2 (4%) patients. Conclusion: A high index of suspicion and early surgical treatment determine the successful management of traumatic diaphragmatic injury with or without the herniation of abdominal organs. The surgical approach is individualized. We prefer the thoracic approach adding laporotomy when necess ary.