Life-threatening bacterial infections have been managed by antibiotics for years and have significantly improved the wellbeing and lifetime of humans. However, bacteria have always been one step ahead by inactivating the antimicrobial agent chemically or by producing certain enzymes. The alarming universal occurrence of multidrug-resistant (MDR) bacteria has compelled researchers to find alternative treatments for MDR infections. This is a menace where conventional chemotherapies are no longer promising, but several novel approaches could help. Our current review article discusses the novel approaches that can combat MDR bacteria: starting off with potential nanoparticles (NPs) that efficiently interact with microorganisms causing fatal changes in the morphology and structure of these cells; nanophotothermal therapy using inorganic NPs like AuNPs to destroy pathogenic bacterial cells; bacteriophage therapy against which bacteria develop less resistance; combination drugs that act on dissimilar targets in distinctive pathways; probiotics therapy by the secretion of antibacterial chemicals; blockage of quorum sensing signals stopping bacterial colonization, and vaccination against resistant bacterial strains along with virulence factors. All these techniques show us a promising future in the fight against MDR bacteria, which remains the greatest challenge in public health care.
Based on the prevailing energy crisis, it is reasonable for the Cement industry of Pakistan to look for alternate sources of electricity generation. The decision of selecting a CPP (Captive Power Plant) depends on a broad variety of parameters which may be conflicting to each other. A comparative evaluation of these CPP's should be helpful for industry, particularly if the applied methodology can handle with the real world ambiguities and imprecisions associated with the data pools and expert opinions. This paper utilizes an F-AHP (Fuzzy Analytical Hierarchy Process) based multi-attribute framework to prioritize the affecting parameters and assign rankings to the CPP alternatives. The CPP's recommended by experts for this study are RDF-CPP (Refused Derived Fuel CPP), CF-CPP (Coal Fired CPP) and WHR-CPP (Waste Heat Recovery CPP). The factors affecting the decision of selecting the optimum CPP are prioritized by the experts using our F-AHP approach. Real world quantitative data is extracted from different online resources and financial reports of cement companies in Pakistan. The F-AHP model is flexible enough to deal with a variety of inputs including qualitative scales, crisp values and standard fuzzy numbers. The model is solved and a sensitivity analysis is performed in respective software. This study shows that non-conventional CPPs are highly demanded for cement industry in Pakistan and while selecting these CPPs, management gives high priority to factors like 'automation' and 'environment' whereas associated 'initial cost' is not given much weight in decision making. In concluding ranking list, WHR-CPP is at the top and CF-CPP is at the bottom. This study may facilitate decision makers of cement industry in Pakistan and international CPP manufacturers alike in their forthcoming strategic decisions.
<span>Beam steering antennas is essential part of various WCN (Wireless Communication Networks) such as radar and satellite communication. The increasing demand of high data rate, high SNR (Signal to Noise Ratio) and high gain, therefore pattern reconfigurable antennas are required to improve such properties. </span><span>Beam steering is the technique of changing the main lobe direction of radiation. The constructive and distractive interference are used to steer the lobe in specific direction. Beam steering is necessary in various communications such as localization, satellite, tracking system and airborne application.</span><span> Beam steering antenna decreases interference and power consumption and also increases directivity and gain. Beam steering antenna transmit and receive signals in specific direction. </span><span>Beam steering antenna decreases interference and power consumption and also increases directivity and gain. The researchers are interested to find optimal beam steering solution for single and multi-point application. </span><span>In past various techniques are used to achieve beam reconfigurable antennas. This paper presents, beam steering principle and their theory, beam steering techniques such as; Mechanical Steering, Beamforming, Switching Pin Diodes, Reflector and array antenna (Reflectarray), Parasitic Steering, Phase Shifters, Switched Beam Antennas, Metamaterial Antennas, Traveling Wave Antennas, Retro-directive Antennas, Integrated Lens Antennas (ILAS), merits and demerits and comparison among various techniques.</span>
EDMed (Electric Discharge Machined) surfaces are unique in their appearance and metallurgical characteristics, which depend on different parameter such as electric parameters, flushing method, and dielectric type. Conventionally, in static workpiece method the EDM (Electric Discharge Machining) is performed by submerging both of the tool and workpiece in dielectric liquid and side flushing is provided by impinging pressurized dielectric liquid into the gap. Another flushing method has been investigated in this study, in which, instead of side flushing the rotation motion is provided to the workpiece. Surface characteristics for both flushing methods are determined and compared in this study. The investigated surface characteristics are: surface roughness, crater size, surface morphology, white layer thickness and composition. These investigations are performed using optical and SEM (Scanning Electron Microscope). Statistical confidence limits are determined for scattered data of surface roughness. It is found that the white layer thickness and surface roughness are directly proportional to discharge current for both flushing methods. The comparison has shown that the side flushing of statics workpiece gives thicker white layer and lower surface finish as compared to the flushing caused by the rotation of workpiece.
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