Insights into protein folding rely increasingly on the synergy between experimental and theoretical approaches. Developing successful computational models requires access to experimental data of sufficient quantity and high quality. We compiled folding rate constants for what initially appeared to be 184 proteins from 15 published collections/web databases. To generate the highest confidence in the dataset, we verified the reported lnk f value and exact experimental construct and conditions from the original experimental report(s). The resulting comprehensive database of 126 verified entries, ACPro, will serve as a freely accessible resource (https://www.ats. amherst.edu/protein/) for the protein folding community to enable confident testing of predictive models. In addition, we provide a streamlined submission form for researchers to add new folding kinetics results, requiring specification of all the relevant experimental information according to the standards proposed in 2005 by the protein folding consortium organized by Plaxco. As the number and diversity of proteins whose folding kinetics are studied expands, our curated database will enable efficient and confident incorporation of new experimental results into a standardized collection. This database will support a more robust symbiosis between experiment and theory, leading ultimately to more rapid and accurate insights into protein folding, stability, and dynamics.

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Memory institutions must be able to grow a fully-functional repository incrementally as collections grow, without expensive enterprise storage, massive data migrations, and the performance limits that stem from the vertical storage strategies. The Digital Repository at Scale that Invites Computation (DRAS-TIC) Fedora research project, funded by a two-year National Digital Platform grant from the Institute for Museum and Library Services (IMLS), is producing open-source software, tested cluster configurations, documentation, and best-practice guides that enable institutions to manage linked data repositories with petabyte-scale collections reliably. DRAS-TIC is a research initiative at the University of Maryland (UMD). The first DRAS-TIC repository system, named Indigo, was developed in 2015 and 2016 through a collaboration between U.K.-based storage company, Archive Analytics Ltd., and the UMD iSchool Digital Curation Innovation Center (DCIC), through funding from an NSF DIBBs (Data Infrastructure Building Blocks) grant (NCSA “Brown Dog”). DRAS-TIC Indigo leverages industry standard distributed database technology, in the form of Apache Cassandra, to provide open-ended scaling of repository storage without performance degradation. With the DRAS-TIC Fedora initiative, we make use of the Trellis Linked Data Platform (LDP), developed by Aaron Coburn at Amherst College, to add the LDP API over similar Apache Cassandra storage. This paper will explain our partner use cases, explore the system components, and showcase our performance-oriented approach, with the most emphasis given to performance measures available through the analytical dashboard on our testbed website.

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