psoriasis were as follows: 13% were currently taking a biologic, 42% would consider taking a biologic, 17% had previously taken a biologic, and 24% would not consider taking a biologic. Hierarchical and non-hierarchical cluster analyses were applied to the moment-to-moment affect traces that identified four unique patient clusters (# 1-4). MDA was used to identify the five most impactful time periods within the focus group audio segments. Cluster composition profiles were identified based upon demographic information and patient responses to behavioral and attitudinal questions. CONCLUSIONS: Understanding complex patient perspectives on coping with disease is essential for delivering appropriate treatments over the lifelong course of psoriasis. This novel methodology begins to bridge this knowledge gap in understanding the patient-centered view of psoriasis. Furthermore, it improves the likelihood of recommending treatments in alignment with the patient's needs to improve health-related quality-of-life, productivity, and well-being.
OBJECTIVES:Currently in Brazil's public healthcare, patients with psoriasis who fail the available treatment options (phototherapy, methotrexate, acitretin and cyclosporin) due to any cause, are experiencing a medical unmet need. This study is aimed to assess comorbidity, quality of life (QoL), work/productivity loss (WPL), and medical resource utilization in patients diagnosed with psoriasis (PdwP) in Brazil. METHODS: A total of 12,000 individuals' (age 18ϩ) self-reported data were collected from 2011 National Health and Wellness Survey (NHWS) in Brazil, a crosssectional representative sample of the adult population. QoL was measured by the physical component score (PCS) and mental component score (MCS) of the Short Form-12 (SF-12). WPL was measured by the validated Work Productivity and Activity Impairment instrument. Medical resource utilization was measured by health care provider utilization, emergency room visits and hospitalization in the past 6 months. RESULTS: Of the 12,000 respondents, 205 (1.3%) were patients diagnosed with psoriasis (PdwP) (53.0% women). Mean age was 40.2. Higher percentage of co-morbidities was found among PdwP compared to patients not diagnosed with psoriasis (PndP): headache (71% vs. 54%), sleep difficulties (50% vs.24%), anxiety (50% vs.33%), insomnia (46% vs.22%), pain (42% vs.23%), skin allergies (40% vs.17%), migraine (40%vs.20%), Heartburn (38% vs.23%) hay fever (37% vs.15%), nasal allergies (33% vs.21%), depression (33% vs.16%), rhinitis (32%vs.11%), high blood pressure (29% vs.16%), gingivitis (22%vs.6%), nail fungus (20%vs.7% ), dry eye (20% vs.5%), anemia (19% vs.6%), diabetes type 1 or 2 (19% vs.4%). PdwP had a lower mean PCS (45.8 vs. 49.7) and MCS (42.3 vs.47.0), more visiting health practitioners (87.0% vs.76.0%), emergency room visits (36.0%vs.22.0%), and hospitalizations for a medical condition (21.0% vs.10.0%) over the past 6 months compared to the PndP group. Furthermore, PdwP reported higher presenteeism (30.4% vs.14.8%), work producti...
