Periodontitis is a chronic inflammatory condition of tooth supporting structures that may lead to tooth loss. Periodontitis has been considered as a risk factor for various systemic diseases that affect the human health. Cardiovascular Diseases is one of them. The various systemic inflammatory markers associated with Cardiovascular Diseases, actually increase the inflammatory activity in atherosclerotic lesions, potentially increasing the risk for cardiac or cerebro vascular events. Amongst the different inflammatory markers, plasma Fibrinogen is a classical positive acute-phase reactant considered to be an independent predictor of coronary heart disease. Various studies have shown that periodontitis is responsible for increase in systemic inflammatory markers. Very few studies have mentioned about the increase inPlasma fibrinogen levels in chronic periodontitis subjects. This pilot study was therefore planned to assess plasma fibrinogen levels in chronic periodontitis subjects.