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BACKGROUND As we progressed from operations involving multiple ports to single access through umbilicus, there is empirical evidence that postoperative pain can be reduced as a result of single incision, in addition to accomplishing the laparoscopic procedure effectively and safely. This study was conducted to evaluate safety, efficacy and postoperative morbidity with this method. MATERIALS AND METHODSThis case series was conducted on forty patients suffering from cholelithiasis, who met the inclusion criteria were selected for single port laparoscopic cholecystectomy (SPLC) over a period of one year. SPLC was performed using X-cone device in twenty patients and multiport through a single periumbilical incision in twenty patients. RESULTSThe perception of pain was very less in immediate postoperative period and no patient required analgesics beyond one week. Early ambulation and early return to normal activity was observed. CONCLUSIONSPLC is going to develop a platform of its own or lead us down the path we have not yet realised and will certainly become apparent over the next decade. It has become patient-demanding procedure, because of excellent cosmetics and satisfaction with body image with decreased postoperative pain, early ambulation and return to day-to-day activity. Whichever direction we go in, the driving force needs to be patient's safety and patient care about which we have concluded in our study. KEY WORDSSingle Port Laparoscopic Cholecystectomy, Single Incision Laparoscopic Surgery, X-Cone, Single-Incision Cosmesis. HOW TO CITE THIS ARTICLE: Pathania BS, Raina AW. Our experience with single-incision laparoscopic cholecystectomy.