Renewable power plants contribute almost insignificantly in the country's electricity supply. Due to the environmental uncertainty and the rapid development of modern technology in the recent century, it is usually necessary to predict future situations using insufficient data over a short period. Renewable fuels and biofuels as a significant replacement for fossil fuels have been of great interest in recent decades. Optimum design of supply chains is an essential requirement for the commercial production of biofuels. This research has employed mathematical optimization and a mixed integrated linear programming (MILP) approach for the feedstock pathway to the fuel supply chain (BSC) scenario. The further examination includes the effect of the autoregressive moving average (ARMA) time series structure for the demand of biofuels on the design of the supply chain. After developing the model, a numerical example of 8 years was used in the supply chain to gain a wider perspective. The results showed that the optimal cost can be determined and 4 valid locations were adopted out of 10 proposed refinery building sites. Finally, it evaluates and validates the proposed model with experimental results.