<p class="abstract"><strong>Background:</strong> Humeral shaft fractures are those fractures of the diaphysis of the midshaft that do not involve the proximal or distal articular joints. Humerus fractures have a substantial impact on personal function and well‐being and are one of the causes of excessive mortality among the elderly. The aim and objective of the study was to study the functional assessment after interlocking nailing in fractures of shaft humerus.</p><p class="abstract"><strong>Methods:</strong> A retrospective clinical study was done on 20 patients with shaft humerus fractures treated with intramedullary nailing by orthopaedic surgeons at a tertiary care centre in the Department of Orthopaedics, Indian Institute of Medical Science and Research, Noor hospital, Jalna between January 2020 to July 2020 (DASH Score being calculated till January 2021). The DASH score was assessed 6 months post-operative day of surgery.</p><p class="abstract"><strong>Results: </strong>For all the operated patients clinical, physiological and ortho-radiological assessment were performed to observe and evaluate fracture stabilization, reduction, fracture healing and callus formation, functional evaluation done with DASH scoring system.</p><p class="abstract"><strong>Conclusions:</strong> Closed intramedullary nailing is safe and reliable technique to fix humeral shaft fracture. It provides early fracture consolidation, with high union rate, with advantage of early mobilization of the involved limb.</p><p class="abstract"> </p>