physicochemical properties that are entirely different from those of their bulk counterparts. They have been exploited vigorously for numerous applications, including in medical and nonmedical fields. However, one must not realize it to be a novel technology, as its roots can be traced centuries ago. For instance, copper and silver (Ag) NPs can be dated back to the 9 th century, when they were used to shine the ceramic artifacts. [1] One of the earlier and renowned examples is the Lycurgus cup, made by the Romans in the 4 th century using Au-Ag alloy NPs to produce greenish-red color. [2] Even though the use of NPs could be found in many such old works of literature; their real potential was not completely understood until 1959, when Richard Feynman delivered the renowned lecture "There's Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics. [3] This brought in a stream of exceptional studies, and researchers were able to assign quantum size effects as the reason for a change of properties when moving from bulk to nano regime. As things became more and more precise, nanomaterials began to find their extensive role in varied applications. One of the significant applications was their role as enzyme mimetics due to their excellent catalytic properties.The metabolic reactions in our body are catalyzed by the protein molecules called enzymes. It was James B Sumner who, in 1926, established the first enzyme, urease, to be a protein, which won him a Nobel Prize for this discovery in 1946. [4] All the enzymes have been considered protein molecules ever since. However, due to their high production cost and rapid denaturation under variable pH and temperature settings, they have limited their industrial applications. [5] Therefore, a need was felt to develop enzyme mimicking materials, more precisely termed "artificial enzymes" by Robert Breslow. [6] These catalytically active molecules can be anything from polymers, cyclodextrins to supramolecules and dendrimers, showing enzyme-like activity. [7][8][9][10] Recently, the discovery of dismutaselike activity of fullerene derivatives [11,12] and peroxidase-mimicking catalysis of Fe 3 O 4 NPs [13,14] enunciated the promising career of NPs in the field of biomimetics. The importance and broad prospect of nanozymes can be understood in Figure 1. This shows the increasing number of publications each year on nanozymes. These nanozymes have been majorly used Natural enzymes accelerate substrate-specific reactions making them of exquisite interest for various applications. However, their appeal is lost in a practical setting due to low stability and high preparation expenses. This is the primary reason behind the flourishing in the research of nanozyme, i.e., artificial enzymes, in the past decade. Their unique physicochemical properties make them a promising candidate for various applications, especially in diagnostics and detection. They possess an enzyme-like activity and can overcome the drawbacks of natural protein-based enzymes. Nanozymes are nanomateri...