Hydroferrate fluid, MRN-100, an iron-based compound derived from bivalent and trivalent ferrates, is a potent antioxidant compound. Therefore, we examined the protective effect of MRN-100 against γ-radiation-induced lethality and damage to hematopoietic tissues in fish. A total of 216 Nile tilapia fish (Oreochromis niloticus) were randomly divided into four groups. Group 1 served as a control that was administered no radiation and no MRN-100 treatment. Group 2 was exposed only to γ-radiation (15 Gy). Groups 3 and 4 were pre-treated with MRN-100 at doses of either 1 ml/l or 3 ml/l in water for 1 week, and subsequently exposed to radiation while continuing to receive MRN-100 for 27 days. The survival rate was measured, and biochemical and histopathological analyses of hematopoietic tissues were performed for the different treatment groups at 1 and 4 weeks post-radiation. Exposure to radiation reduced the survival rate to 27.7%, while treatment with MRN-100 maintained the survival rate at 87.2%. In addition, fish exposed to γ-radiation for 1 week showed a significant decrease in the total number of white blood cells (WBCs) and red blood cells (RBCs) series. However, treatment with MRN-100 protected the total WBC count and the RBCs series when compared with irradiated fish. Furthermore, significant histological lesions were observed in the hepatopancreas, spleen and gills of irradiated fish. However, treatment with MRN-100 protected the histopathology of various organs. We conclude that MRN-100 is a radioprotective agent in fish and may be useful as an adjuvant treatment to counteract the adverse side effects associated with radiation exposure.

This study was conducted to assess the effect of different levels of Aqua-Max Plus ® on growth performance, feed efficiency, body chemical composition, hematological, and biochemical of the mono-sex Nile tilapia (Oreochromis niloticus, L. 1758) for 147 days (21 weeks). Aqua-Max Plus ® was added at five levels (0, 1, 2, 3, 4 g/kg diet). Results exhibited that the addition of Aqua-Max Plus ® at levels 2, 3, and 4 g/kg diet (T 3 , T 4 , and T 5 ) led to significantly improve the growth performance and feed efficiency parameters compared to the control group. By increasing the levels of Aqua-Max Plus ® , ash and protein contents were significantly increased, while fat and energy content contents were decreased. No significant differences among treatments in hematological and serum biochemical parameters were detected. Thus, based on the obtained results, it could be concluded that the beneficial addition of 2 g Aqua-Max Plus ® / kg diet as a growth promoter agent for the Nile tilapia.

The aim of this experiment was to investigate the effect of aflatoxin B (AFB) in the diets of Nile tilapia (Oreochromis niloticus) and to examine the detoxification activity of a commercial anti-mycotoxin ARCAVIT ® Bioacid Forte. The experimental period lasted 70 days during September-December 2018. Sixty fish were chosen with an average initial weight of about 40 g then randomly distributed into three treatments in six glass aquaria (30 × 60 × 40 cm); each treatment was applied in two aquaria (replicates). Dietary AFB was added at a concentration of 5 ng / g diet. The anti-mycotoxin ARCAVIT ® (pro-and prebiotics) is one of the commercial anti-mycotoxins in the local market. It is the first test for it in aquaculture, which was added at a concentration of 0.5 g/Kg diet. The experimental diets of the three treatments were; the control treatment (T 1): the basal diet (BD) without any additives. The second treatment (T 2): BD with an addition of 5 ng AFB / g diet. The third treatment (T 3): BD with an addition of 5 ng AFB / g diet and 0.5g ARCAVIT ® / Kg diet. Fish fed the experimental diets at a daily rate of 3% of their live body weight, at two meals. The obtained results showed that AFB is very toxic, even at a low concentration as 5 ng / g diet, for Nile tilapia. It threats fish morphology, gross pathology, liver histology, growth performance, and internal organs indices, feed utilization, body composition, and properties, as well as hematological and plasma biochemistry parameters. Moreover, the anti-toxic agent (ARCAVIT ®) at the tested level did not completely overcome the aflatoxicity symptoms. That leads to keep the old wisdom "Prophylaxis is better than cure". 1985 and Kumar et al., 2018) and to control mycotoxicoses (Abdelhamid and Mahmoud, 1996; Abdelhamid et al., 2002a, b &c; 2004 a, b &c and 2007). All these attempts concluded that exact overcome of mycotoxicoses is impossible, so recommended the prevention (Prophylaxes that is better than cure). Hence, the aim of the present research was to study the effects of a new commercial feed additive aiming in ameliorating fish aflatoxicosis. MATERIALS AND METHODS Experimental fish: Unsexed Nile tilapia fingerlings collected from Lake Manzala in September 2018 and transferred to Elmataria Station for Aquatic Research, Dakahlia Governorate, National Institute of Oceanography and Fisheries, Egypt in order to investigate the effect of aflatoxin B (AFB) in the diets of Nile tilapia (Oreochromis niloticus) and to examine the detoxification activity of a commercial anti-mycotoxin ARCAVIT ® Bioacid Forte (Italy Product) distributed in Egypt by ALLgaeuvet Egypt. The experimental period lasted 70 days (10 weeks). The experiment started on 15 th of September 2018 and finished on the 2 nd of December 2018. After 2 weeks adaptation period in a 3m 3 fiberglass tank; during that period, fish were fed a basal diet (BD) from Bio Feed Factory (Asafra Industrial zone, Dakahlia governorate, Egypt). Fish (40 g initial body weight) were randomly distributed into three treatments i...

his experiment was designed to estimate the effect of different levels of dietary protein with the addition of Aqua-Max Plus ® (as a feed additive) on growth performance, feed utilization, the chemical composition of the whole fish body, and physiological responses of mono-sex Nile tilapia, Oreochromis niloticus. Six hundred of mono-sex Nile tilapia fingerlings (at average initial bodyweight 52.64 ± 5.2 g) were distributed randomly to five treatments. Experimental diets contain different levels of dietary crude protein 21, 23, 25, 27% (referred to No. T1, T2, T3, and T4, respectively) and that were compared to the control diet contains 25% without adding Aqua-Max Plus ® (T0). Results revealed that the increasing dietary protein in diets leads to an improvement in growth performance and hematological parameters as well as total protein, albumin, and globulin concentrations in blood serum. Fish fed on a diet containing 21% protein (T1) recorded the lowest values of growth performance, feed efficiency, and hematological parameters. The addition of Aqua-Max Plus ® to diets containing 23% (T2) and 25% (T3) crude protein enhanced growth performance and feed efficiency parameters compared to the control diet. Protein content was significantly improved, whereas fat, ash and EC contents were reduced by increasing the dietary protein. The addition of Aqua-Max Plus ® to the experimental diets had no significant effect on serum biochemical parameters. Finally, the addition of Aqua-Max Plus ® in the Nile tilapia diets improve the nutritional values of low protein diets, and it is a way to reduce the cost of fish feed.