Key words:camel; epidural analgesia; lidocaine;lidocaineketamineThe aim of the present study was to evaluate the sedative, analgesic, clinicophysiological and hematobiochemical effects of lidocaine alone or in combination with ketamine when administered epidurally in camels. 8 clinically healthy camels of both sexes were divided equally into two groups, group I was injected with 1.1 mg/kg lidocaine HCl 2 %, while group II was injected with combination of lidocaine HCl (1.1 mg/Kg) and Ketamine -HCl (1 mg/Kg). The drugs were injected in the 1 st inter coccygeal space. The onset and duration of sedation and analgesia were recorded. Pulse rate, respiratory rate, rectal temperature and hematobiochemical parameters were recorded before drug administration then at 15, 30, 60, 90 and 120 minutes postinjection. Lidocaine/ketamine combination resulted in significant longer duration of both sedation and analgesia when compared with lidocaine alone; recumbancy was recorded after pronounced ataxia after lidocaine/ketamine combination. Significant changes in hematobiochemical parameters were observed in both groups. It was concluded that epidural administration of lidocaine-ketamine combination resulted in more reliable onset and duration of perineal analgesia in camels as compared with lidocaine alone.