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Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles under the following conditions: Creative Commons Attribution-Share Alike 4.0 International Public License (CC BY-SA 4.0).

Background: Warts are benign skin lesions that occur as a result of infection with human papillomavirus (HPV). Warts are classified according to their sites and shapes as (i) Common wart; (ii) Plantar wart; (iii) Plane wart and (iv) Genital wart (condyloma accuminatum). The type of wart present on the plantar surface of the foot is called planter wart and there are various types of HPV have been identified to cause planter warts including HPV-1, -2, -3, -4, -27, -29, -57, -60, -63, -65, -66, and -69. It has been already established that radical treatment of warts is often challenging for both the physician and the patient. Aim of the study: To assess the effectiveness of Intralesional Methotrexate in comparison with 5-Flurouracil in treatment of Plantar Warts. Patients and Methods: The study was carried out on 40 patients with planter warts. Two groups of patients were obtained. Group A included 20 patients were injected MTX in full concentration into the base of the wart and Group (B) included 20 patients were injected intralesional 5 Fluorouracil in full concentration.Results: There is a significant difference between the two groups as regard the response (Group B -5-FU group-is more effective) with no statistical significant difference between the 2 groups as regard the type, number, duration of warts or the complications of injection. Conclusion: MTX is less effective than 5-FU in treating plantar warts.

Background: Peyronies disease (PD) is a physically and psychologically debilitating illness marked by a fibrous inelastic tunica albuginea scar that results in a visible penile scar and deformity. Aim of the study: To assess the efficacy of intralesional injection of platelet rich plasma to Mitomycin-C with Dexamethasone in the treatment of Peyronie's Disease, researchers conducted a study. Patients and Methods: This study was Prospective interventional randomized comparative trial carried out on adult's male Patients with Peyronie's disease who visited the Andrology outpatient clinic, Kasr El Aini Hospital, and Cairo University . Only 50 patients with Peyronie's disease were included in the first screening of 75 patients who complained of PD. The study enrolled those who met the inclusion criteria. Results: There was a statistically significant improvement in PDQ domains, and IIEF scores after treatment with no superiority of neither option. Additionally, degree of curvature and erectile dysfunction improved in both groups after treatment as well; but to a different extent. Conclusion: Intralesional injection of PRP and Mitomycin-C plus Dexamethasone could improve Peyronie's Disease symptoms. Mitomycin-C plus Dexamethasone more effective than PRP Penile curvature and plaque size improvement, while PRP was more effective in improvement of erectile function.