Fever, dullness, tachypnea, bilateral nasal discharge, cough, dyspnea, and abnormal lung auscultation were all symptoms of pneumonic goats. To evaluate the hematological, biochemical and pulmonary function changes in 45 pneumonic goats compared with 10 apparently healthy ones, whole blood and serum samples were collected. The results revealed that pneumonic goats had significantly lower (P<0.05) RBCs, Hb, and PCV levels than healthy goats. A decrease in lymphocyte count and an increase in WBCs and neutrophils were found to be significant (P<0.05) in pneumonic goats compared to healthy ones. Blood pH and pO2 were significantly reduced (P<0.05) while pCO2, tCO2, and HCO3 were significantly elevated (P<0.05) in pneumonic goats compared to healthy ones. Biochemically, K, MDA, Hp and SAA showed significant (P<0.05) increase, whereas Cl and TAC showed a significant (P<0.05) decrease in the pneumonic goats compared to control group. The echotexture of the pneumonic consolidation on ultrasound resembles that of the liver. The chest x-ray showed increased opacity with a cotton-wool-like look that may be more grey or white. According to the findings, the diagnostic techniques mentioned above are helpful in diagnosing goat pneumonia. So, this study aimed to evaluate some selected biochemical parameters and different diagnostic methods including ultrasonography and radiography in pneumonic goats.