Remote sensing (RS) and Geographic Information Systems (GIS) have become widely used in various fields around the world in recent years. In this paper; we attempt to delineate the groundwater potential zone in the transboundary watershed of Chott-El-Gharbi using the integration of RS, GIS methods. Eight influencing thematic layers viz. geology, rainfall, water table level, lineaments density, slope, drainage density, elevation, and land use/land cover were used. Afterward, Analytical Hierarchy Process technique, which offers good functionality for mapping the groundwater potentiality was used, where ranks and weights, assigned to each factor are computed statistically, based on their relative importance in terms of groundwater potential. Then, groundwater potential zones are classified into five categories namely excellent, high, medium, low, and very low zone, which represent 964.48 km2 (7.33%), 1467.30 km2 (11.15%), 7969.51 km2 (60.57%), 2639.52 km2 (20.06%), and 116.19 km2 (0.88%) of the study area, respectively. The very low potential region is found in the southern region of the study area, which is covered by mountains. Moreover, excellent groundwater potential zones are located at the central part of the region of Chott, which has quaternary formations where the infiltration is high. On the other hand, moderate and poor groundwater potential zones cover by the bare lands in the study area. Finally, the results were carefully validated with the yields data of various boreholes in the study area, which reveals an accuracy achievement of 72.41%. The finding of this research constitutes a valuable contribution towards the water resources management, and it forms a significant decision support tool for equitable and sustainable utilization of groundwater resources in the transboundary watershed of Chott-El-Gharbi. The study's findings will also serve as a benchmark for future research and studies, such as hydrogeological modeling.