Background: Home delivery is childbirth in a non-clinical setting that takes place in residence than in health institution. Globally, every day more than 800 women died due to complications during pregnancy or childbirth. In Ethiopia, few are known about the factors that affect women's place of delivery after utilization of antenatal care service. Therefore, the aim of this study was to assess the magnitude of home delivery and associated factors among antenatal care booked mothers in Delanta district, North east Ethiopia. Methods:A community-based Cross-sectional study design was conducted from March 15 to 30, 2018. Multistage sampling methods were applied to select 576 respondents among mothers booked for antenatal care. Data was collected through face to face interview using pretested questionnaire. Epi-Data version 3.1 and statistical package for social science (SPSS) version 21 were used for data entry and analysis respectively. Binary and multivariable logistic regression analyses were used to identify any statistically significant association existed between dependent and independent variables. P-value < 0.05 was declared as statistical significance level. Result:The prevalence of home delivery after ante natal care (ANC) follow up among mothers who gave birth in the last one year was 196 (35.2%). The factors associated with home delivery were age of the mothers between 20-24 years (AOR = 0.089, 95% CI [0.043, 0.184]), occupation of the mothers (AOR = 3.422, 95% CI [1.557, 7.524]), nonexposed to media (AOR =1.979, 95% CI [1.149, 3.410]), having first antenatal care) visit (AOR = 3.217, 95% CI [1.575, 6.570]) and distance (time taken) between 90-120 minutes to reach health facility on foot (5.459, 95% CI [1.681, 17.732]). Conclusion and recommendation:The magnitude of home delivery after ante natal care follow up in Delanta district was high. Distance, age and occupation of the mothers, number of ANC visit and non-media exposure were statistically significant association with home delivery. The district should better enhances geographic access to a health facility, gives awareness on the importance of media exposure and the health professionals should visit mothers if they miss the next appointment in ANC follow up care.