Introduction- Spondyloarthritis is classically considered rare in sub-Saharan Africa where the majority of the population is considered HLA-B27 negative.The objective of this study was to describe the profile of spondyloarthritis in the rheumatology department of the Ignace Deen National Hospital in Conakry, Guinea. Patients and method -This was a descriptive and analytical cross-sectional study, with both prospective and retrospective data collection over a 4-year period. The diagnosis of SpA was made in accordance with the ASAS (Assessment of Spondyloarthrisis) and modified New York criteria. Results -During the study period, we evaluated 275 patients with spondyloarthritis. The mean age was 39.7 ±11 years with extremes (20 and 75 years), 150 patients (54.5%) were men. A history of familial SpA was present in 95 (34.5%) of the patients. The mean time to diagnosis was 8 ± 4 years. Axial involvement was dominated by involvement of the lumbar spine 225 (82%). Ankylosing spondylitis was the most common form in 198 (72%) of the cases. Extra-articular manifestations were dominated by uveitis in 55 (20%) of cases. HLA-B27 phenotyping was performed in 125 patients, 62 patients were HLA-B27 positive (49.6%). The treatment was based on nonsteroidal anti-inflammatory drugs 225 (81.8%). Conclusion -SpA are growing in Guinean hospitals, the HLA-B27 antigen is increasingly found in African series. Treatment is mainly based on non-steroidal anti-inflammatory drugs.

Introduction: Ankylosing spondylitis (AS) is an inflammatory rheumatic disease characterized by predominant axial and peripheral (enthesitis, sacroiliitis) involvement affecting young subjects aged 30 to 40 years, 80% to 98% of cases are associated with HLA-B27. Objective: To determine the epidemiological profile of ankylosing spondylitis in the rheumatology department of the Ignace Deen National Hospital in Conakry (Guinea). Materials and Methods: This was a descriptive cross-sectional study carried out within the said department over a period of 18 months from July 1, 2018 to December 31, 2020, including all patients seen in consultation and/or hospitalized in the department in which the diagnosis of ankylosing spondylitis had been retained according to the modified New York criterion. The parameters studied were sociodemographic, clinical, paraclinical and therapeutic. Result: We collected 73 cases or 4.1% of ankylosing spondylitis out of a total of 1781 patients seen during the study period. The male gender was represented with 54.8% for a sex ratio of 1.2 M/F. The average age of our patients was 32.18 ± 12.44 years with extremes ranging from 17 to 54 years. Axial involvement was present in 89.9% of cases with a lumbar predominance (95.2%), followed by the sacroiliac seat (35.5%), cervical (14.5%) and dorsal at 4.8%. The pain was chronic in 93.2% of cases. The most common drug treatment was taking analgesics and NSAIDs (100%) followed by cortisone infiltration (41.1%), corticosteroids (30%), and physiotherapy (21.9%). Ankylosing spondylitis represents 83% of spondyloarthritis followed by undifferentiated spondyloarthritis (9.1%) and juvenile spondylitis (3.4%) were the most common conditions.