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This article summarizes concepts, methods, cross‐cultural evidence, and implications of parental acceptance‐rejection theory (PARTheory). The theory focuses primarily on parental love—its expressions, impact, and origins. Nearly 2,000 studies in the United States and cross‐culturally confirm the widely held belief that children everywhere need acceptance (love) from parents and other attachment figures. Evidence has shown that when this need is not met, children worldwide—regardless of variations in culture, gender, age, or ethnicity—tend to self‐report a specific form of psychological maladjustment. Additionally, individuals who perceive themselves to be rejected appear to be more disposed than accepted persons to develop behavior problems, depression or depressed affect, substance abuse, and other mental health‐related issues. Finally, children and adults appear universally to organize their perceptions of acceptance‐rejection around the same four classes of behavior. These include warmth/affection (or coldness/lack of affection), hostility/aggression, indifference/neglect, and undifferentiated rejection.

ࡗ Perceived Parental Acceptance-Rejection and Psychological Adjustment: A Meta-Analysis of Cross- Cultural and Intracultural StudiesMeta-analytic procedures were used to pool information from 43 studies worldwide to test one of the major postulates of parental acceptancerejection theory (PARTheory). Specifically, using child and adult versions of the Parental Acceptance-Rejection Questionnaire (PARQ) and the Personality Assessment Questionnaire (PAQ), these studies allowed us to assess the claim within PARTheory's personality subtheory that perceived parental acceptance-rejection is associated universally with a specific form of psychological (mal)adjustment among children and adults, regardless of differences in gender, race, geography, language, or culture. Results of the analysis showed that the predicted relation emerged without exception in all studies. The mean weighted effect sizes across the full range of sociocultural and ethnic groups studied were r ϭ .51 for children and r ϭ .46 for adults. Analysis of fail safe N showed that 3,433 additional studies, all with nonsignificant results, would be required to disconfirm the pancultural association between the PARQ and PAQ among children; 941 such studies would be required to disconfirm this relation among adults.

Heat shock proteins (HSPs) are thought to play a role in the development of cancer and to modulate tumor response to cytotoxic therapy. In this study, we have examined the expression of hsf and HSP genes in normal human prostate epithelial cells and a range of prostate carcinoma cell lines derived from human tumors. We have observed elevated expressions of HSF1, HSP60, and HSP70 in the aggressively malignant cell lines PC-3, DU-145, and CA-HPV-10. Elevated HSP expression in cancer cell lines appeared to be regulated at the post-messenger ribonucleic acid (mRNA) levels, as indicated by gene chip microarray studies, which indicated little difference in heat shock factor (HSF) or HSP mRNA expression between the normal and malignant prostate cell lines. When we compared the expression patterns of constitutive HSP genes between PC-3 prostate carcinoma cells growing as monolayers in vitro and as tumor xenografts growing in nude mice in vivo, we found a marked reduction in expression of a wide spectrum of the HSPs in PC-3 tumors. This decreased HSP expression pattern in tumors may underlie the increased sensitivity to heat shock of PC-3 tumors. However, the induction by heat shock of HSP genes was not markedly altered by growth in the tumor microenvironment, and HSP40, HSP70, and HSP110 were expressed abundantly after stress in each growth condition. Our experiments indicate therefore that HSF and HSP levels are elevated in the more highly malignant prostate carcinoma cells and also show the dominant nature of the heat shock-induced gene expression, leading to abundant HSP induction in vitro or in vivo.