Cutaneous leishmaniasis (CL) has historically been present in Syria, mainly in the western part of the country. The present study was conducted to evaluate kidney function parameters in patients infected with CL in Idlep-Syria. This is controlled study contain infected (60) and control (30) groups. The prevalence and distribution of infection were studied, kidney function testes were determined by colorimetric methods, (Biosystem ®). Among 100 of a total cases studied, the percent of infected cases are 60 % and not infected are 40%. The distribution of lesions on various parts of body in patients shows the highest percent of infection was in face (50%). There were highly significant increase in urea, uric acid and creatinine in infected group (p <0.0001) as compared to control one. In the war in Syria, the prevalence of infection was increased and had side effect on kidney parameter in infected patients treated with Glucantime.