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Given the high risk of venous thromboembolism (VTE) post-orthopedic surgery and the vital role of thromboprophylaxis in preventing VTEs, this meta-analysis aimed to assess the efficacy of thromboprophylaxis post major orthopedic surgery and the relevant safety measures. In this review, we conducted a computer-aided search of Google Scholar, PubMed, CINAHL, Cochrane, Medline, and EMBASE databases. We included all published randomized clinical trials (RCTs) that utilized enoxaparin, fondaparinux, dabigatran, rivaroxaban, apixaban, and aspirin for VTE prophylaxis in patients undergoing total hip arthroplasty (THA), hip fracture surgery, and total knee arthroplasty (TKA) based on primary and secondary outcomes. The Cochrane Collaboration tool was used to evaluate the risk of bias. All statistical analyses were performed using Review Manager Software. A total of 23 RCTs were included with a total sample of 48,424 patients and an overall low risk of bias. The efficacy of enoxaparin in preventing VTEs in the TKA group was significantly better than fondaparinux. In the THA group, the efficacy of enoxaparin was significantly better than apixaban. The efficacies of fondaparinux, dabigatran, rivaroxaban, apixaban, and aspirin were comparable to that of enoxaparin in reducing VTE-associated mortality, major bleeding, and adverse events. In conclusion, we found that all included drugs were non-inferior to enoxaparin in VTE-associated mortality, major bleeding, and adverse events.

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Introduction. Dental caries is a serious problem affecting numerous populations around the world. During the last decade, there was a significant increase of its prevalence in many countries. Hence, the dental epidemiological status requires some further analysis. Aim. This study was designed to assess the prevalence of dental caries among adults of various age and gender groups treated by dental students of English Division at the Chair and Department of Conservative Dentistry and Endodontics of the Medical University of Lublin. Material and methods. The authors collected and analyzed the dental history of patients who had been treated at the university dental clinic in Lublin throughout 2013 and 2014. Results and Conclusions. The mean DMFT index of examined group of patients increases with age and it tends to be higher in women than men. Class I dental caries according to Black’s classification was the most prevalent, followed by class II, class III, class V and class IV. Caries tends to affect molars and premolars most commonly. In addition, these teeth were most likely to be extracted and restored.