Periodontal disease denotes a group of oral inflammatory infections. This infectious disease severity varies from minor and reversible gingiva inflammation (gingivitis) to chronic damage of CT. 1 This process causes separation of the gum tissues from the tooth, producing a periodontal pocket and bone loss, which causing tooth loosening. 2 Lipopolysaccharide (LPS) is a main compound present in the membrane of Gram negative bacteria. It has the ability to initiate immune responses by stimulating cells that reside in the periodontal tissues, leading to releasing of large numbers of inflammatory mediators including interleukins, chemokines and adhesion molecules. 3 After recognition and presentation of microbes to the appropriate cells, cytokines of the innate response, including tumor necrosis factor alpha (TNF-α), interleukin-1beta (IL-1β) and interleukin-6 (IL-6), are the first to appear in the periodontal disease pathogenesis pathways. 4 IL-1β and IL-6 are signature innate cytokines and have been characteristically associated with inflammatory cell migration and osteoclastogenesis. 5