Wireless capsule endoscopy is the preferred modality for diagnosis and assessment of small bowel disease. However, the poor resolution is a limitation for both subjective and automated diagnostics. Enhanced-resolution endoscopy has shown to improve adenoma detection rate for conventional endoscopy and is likely to do the same for capsule endoscopy. In this work, we propose and quantitatively validate a novel framework to learn a mapping from low-to-high resolution endoscopic images. We use conditional adversarial networks and spatial attention to improve the resolution by up to a factor of 8×. Our quantitative study demonstrates the superiority of our proposed approach over Super-Resolution Generative Adversarial Network (SRGAN) and bicubic interpolation. For qualitative analysis, visual Turing tests were performed by 16 gastroenterologists to confirm the clinical utility of the proposed approach. Our approach is generally applicable to any endoscopic capsule system and has the potential to improve diagnosis and better harness computational approaches for polyp detection and characterization. Our code and trained models are available at https://github.com/akgokce/EndoL2H.
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