The study was set to investigate the potency of stem bark extract of Sterculia setigera as a hepatoprotective agent against acute administration (overdose) of acetaminophen in experimental animals. Experimental animals were grouped into six treatments with each group containing five rats. Group 1 was the placebo, Group II was the standard treatment orally administered acetaminophen at a dosage of 250 mg/kgbw and thereafter treated with the standard drug silymarin at 100 g/kgbw after 6 h, to Group III (negative treatment) was orally administered acetaminophen only, at a dosage of 250 mg/kgbw without follow up treatment with standard drug (silymarin). Groups IV, V and VI were orally administered 70% methanol stem bark extract at a dosage of 200, 400 and 600 mg/Kgbw six hours after being orally administered with the hepatotoxic acetaminophen. The trial treatment was carried out for a period of three weeks. The inadequacy of herbs used in curing of liver diseases and other dysfunctions caused by allopathic drugs is enough reason to focus on systematic scientific research to evaluate some species of plants that are traditionally claimed to possess hepato-protective activities.

This study was conducted to investigate the effect of Ginger (Zingiber officinale) as an antioxidant and its ability to prevent the effect of H2O2-induced oxidative stress and its reflections on blood parameters and antioxidant status of male quail. 120 local male quail on 21 days aged were randomly distributed according to complete randomized design into 4 groups and reared until 56 days age as follows: Control group, H2O2 group (tap water with 0.5% H2O2), Ginger group (1000 mg ginger/kg ration), H2O2 with Ginger group (1000 mg ginger/kg ration and tap water with 0.5% H2O2). Results revealed that the H2O2 induced oxidative stress retracted the blood parameters and serum antioxidant status (decrease glutathione 1.10 µmol/l and increase malondialdehyde 1.79 nmol/ml), while the ginger enhanced the blood parameters and serum antioxidants status (elevation glutathione 2.92 µmol/l and decline in malondialdehyde 0.41 nmol/ml) compared to the control group (1.58 µmol/l, 0.74 nmol/ml respectively). In conclusion, ginger prevented the oxidative stress effects and returned most of the biochemical values to normal values as in the control group.

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This research was carried out to find out the ability of crushed dry ginger (Zingiber officinale) to recover or prevent the impacts of oxidative stress that is induced by hydrogen peroxide by studying some hematological and productive traits of quail. One hundred fifty sexed male quail (21 days old) were randomly distributed into five groups of 30 birds each (3 replicates). G1: control; G2: H2O2 group; G3: ginger group; G4: H2O2+ginger from the beginning of the experiment; G5: H2O2+ginger after the 2 nd week from the beginning of the experiment. Blood samples were collected at the age of 56 days, and the results showed that the addition of H2O2 led to a significantly increased (p≤0.05) feed consumption compared with other groups and enhanced significantly the feed conversion ratio compared with ginger and the control. Also, H2O2 caused a significant increase in blood glucose levels compared to the ginger group and a significant elevation in cholesterol and triglycerides compared with other groups, while PCV%, hemoglobin, and lymphocytes decreased significantly, which led to a significant elevation in the stress index in comparison to the ginger group. As for the impact of ginger, it was opposite to the effect of hydrogen peroxide, as it significantly reduced feed consumption and lowered blood glucose, cholesterol, and triglycerides, which led to an improvement in the blood picture and a decrease in the value of the stress index for the birds that ate ginger alone or the birds in the groups that ate ginger with hydrogen peroxide.