Angiotensin-converting enzyme 2 (ACE2), also known as peptidyl-dipeptidase A, belongs to the dipeptidyl carboxydipeptidases family has emerged as a potential antiviral drug target against SARS-CoV-2. Most of the ACE2 inhibitors discovered till now are chemical synthesis; suffer from many limitations related to stability and adverse side effects. However, natural, and selective ACE2 inhibitors that possess strong stability and low side effects can be replaced instead of those chemicals' inhibitors. To envisage structurally diverse natural entities as an ACE2 inhibitor with better efficacy, a 3D structure-based-pharmacophore model (SBPM) has been developed and validated by 20 known selective inhibitors with their correspondence 1166 decoy compounds. The validated SBPM has excellent goodness of hit score and good predictive ability, which has been appointed as a query model for further screening of 11,295 natural compounds. The resultant 23 hits compounds with pharmacophore fit score 75.31 to 78.81 were optimized using in-silico ADMET and molecular docking analysis. Four potential natural inhibitory molecules namely D-DOPA (Amb17613565), L-Saccharopine (Amb6600091), D-Phenylalanine (Amb3940754), and L-Mimosine (Amb21855906) have been selected based on their binding affinity (−7.5, −7.1, −7.1, and −7.0 kcal/mol), respectively. Moreover, 250 ns molecular dynamics (MD) simulations confirmed the structural stability of the ligands within the protein. Additionally, MM/GBSA approach also used to support the stability of molecules to the binding site of the protein that also confirm the stability of the selected four natural compounds. The virtual screening strategy used in this study demonstrated four natural compounds that can be utilized for designing a future class of potential natural ACE2 inhibitor that will block the spike (S) protein dependent entry of SARS-CoV-2 into the host cell.

Face detection, which is an effortless task for humans, is complex to perform on machines. The recent veer proliferation of computational resources is paving the way for frantic advancement of face detection technology. Many astutely developed algorithms have been proposed to detect faces. However, there is little attention paid in making a comprehensive survey of the available algorithms. This paper aims at providing fourfold discussions on face detection algorithms. First, we explore a wide variety of the available face detection algorithms in five steps, including history, working procedure, advantages, limitations, and use in other fields alongside face detection. Secondly, we include a comparative evaluation among different algorithms in each single method. Thirdly, we provide detailed comparisons among the algorithms epitomized to have an all-inclusive outlook. Lastly, we conclude this study with several promising research directions to pursue. Earlier survey papers on face detection algorithms are limited to just technical details and popularly used algorithms. In our study, however, we cover detailed technical explanations of face detection algorithms and various recent sub-branches of the neural network. We present detailed comparisons among the algorithms in all-inclusive and under sub-branches. We provide the strengths and limitations of these algorithms and a novel literature survey that includes their use besides face detection.

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This paper examines the relationship of training, job satisfaction, and corporate brand image with employees working performance at British American Tobacco, Dhaka. A significant relationship exists between training and employees’ performance at BAT Dhaka in Bangladesh. To produce better work efforts, it is important to note that job satisfaction influences satisfactory performance output. It is found that brand image psychologically influences and motivates employees and is strongly related to employees working effort. About 100 questionnaires were distributed among the respondents of BAT Dhaka and data were analyzed. Correlation analysis and stepwise regression analysis were performed for testing hypotheses. The research showed that relationships exist between Training, Brand Image, and Job satisfaction among employees working performance.