Scabies is a common skin disorder. It is caused by a mite called Sarcoptes Scabiei. Sarcoptes scabiei is an arthropod that burrows into the skin and live and reproduce there. The class is Arachnida, subclass acari, family sarcoptidae. The mites are usually not seen with naked eye. The parasite burrows into the epidermis of the skin using it as a shelter and it leaves the eggs inside. Scabies is a disease transmitted by direct skin to skin contact with the infected person or with his items such as clothing or blankets used by the infected person and so on.  After a while as an immune reaction this will cause an intense itching and skin rash especially in fingers, axilla, wrists, areola and genitalia. In this comprehensive review study, we are going to discuss the histopathology and life cycle of causative agent, disease transmission, sign and symptoms, prevention and psychosocial impact of an individual