BackgroundAnxiety and depression during the antenatal period is a growing problem with major effects on the mother, the developing fetus, and the neonate.ObjectivesTo assess the prevalence of anxiety and depression during pregnancy in women attending the hospital for antenatal care and assess the associated factors.MethodsThis is a prospective cohort study conducted in the University Hospital of Imam Abdulrahman Bin Faisal University. Anxiety was evaluated using State Trait Anxiety Inventory. Depression was assessed using Edinburgh Postnatal Depression Scale (EPDS).ResultsComplete data were available for 575 women. The mean EPDS score was 10.5 (SD 5.5). The prevalence of depression was 26.8%. The mean state-anxiety score was 38.4 (SD 11.4) and mean trait-anxiety score was 38.2 (SD 9.5). The prevalence of anxiety using state-anxiety scale was 23.6%, while using the trait scale it was 23.9%. The risk is higher among unemployed women with history of miscarriage and unplanned pregnancy.ConclusionAnxiety and depression are common during pregnancy.

Purpose To estimate the prevalence of depression amongst hormonal and non-hormonal contraception users, and the risk factors associated with depression in the sample. Patients and Methods This is a community-based cross-sectional study conducted in the Kingdom of Saudi Arabia from October to November 2021, covering all regions of Saudi Arabia. All participants were women, living in Saudi Arabia, ≥21 years old and ≤45 years old, using a contraceptive method, and with no established history of depression. Results A total of 4853 out of 18,596 met our criteria and were included in this study. Among all sample groups, 29% had moderate to severe depression. Rates of depression and association studies’ results in women using hormonal were higher than those who use non-hormonal birth control methods. Psychiatric disorders, medical illnesses, substance use and depressogenic medication use were all associated with depression in both hormonal and non-hormonal contraception users. Conclusion The current study shows high prevalence of depression amongst hormonal contraceptive users compared to non-hormonal contraceptive users.

Background. There is limited data available on potential biological effects of E-cigarettes on human oral tissues. The aim of this study was to evaluate the effects of E-cigarette liquid on the proliferation of normal and cancerous monolayer and 3D models of human oral mucosa and oral wound healing after short-term and medium-term exposure. Methods. Normal human oral fibroblasts (NOF), immortalized OKF6-TERET-2 human oral keratinocytes, and cancerous TR146 keratinocyte monolayer cultures and 3D tissue engineered oral mucosal models were exposed to different concentrations (0.1%, 1%, 5% and 10%) of E-cigarette liquid (12 mg/ml nicotine) for 1 hour daily for three days and for 7 days. Tissue viability was monitored using the PrestoBlue assay. Wounds were also produced in the middle surface of the monolayer systems vertically using a disposable cell scraper. The alterations in the cell morphology and wound healing were visualized using light microscopy and histological examination. Results. Statistical analysis showed medium-term exposure of TR146 keratinocytes to 5% and 10% E-liquid concentrations significantly increased the viability of the cancer cells compared to the negative control. Short-term exposure of NOFs to 10% E-liquid significantly reduced the cell viability, whereas medium-term exposure to all E-liquid concentrations significantly reduced the NOF cells’ viability. OKF6 cells exhibited significantly lower viability following short-term and mediumterm exposure to all E-cigarette concentrations compared to the negative control. 3D oral mucosal model containing normal oral fibroblasts and keratinocytes showed significant reduction in tissue viability after exposure to 10% E-liquid, whereas medium-term exposure resulted in significantly lower viability in 5% and 10% concentration groups compared to the negative control. There was a statistically significant difference in wound healing times of both NOF and OKF6 cells after exposure to 1%, 5% and 10% E-cigarette liquid. Conclusion. Medium-term exposure to high concentrations of the E-cigarette liquid had cytotoxic effects on normal human oral fibroblasts and OKF6 keratinocytes, but a stimulatory cumulative effect on the growth of cancerous TR146 keratinocyte cells as assessed by the PrestoBlue assay and histological evaluation of 3D oral mucosal models. In addition, E-liquid exposure prolonged the wound healing of NOF and OKF6 oral mucosa cells.

Background: Depression is a primary cause of disability-adjusted life years lost globally. It is a common mental disorder with roughly more than 264 million adults affected. Obesity is another major health problem affecting more than 650 million adults worldwide. The presence of depression and obesity, along with each other, is associated with more negative health outcomes.Objectives: To explore the correlation between depression and obesity among adults in the Eastern Province of Saudi Arabia and analyze this association with other variables, including patients' demographics, body mass index (BMI), and presence of chronic and psychiatric illness.Method: A cross-sectional study was done in the Eastern Province, Saudi Arabia. A total number of 711 participants were enrolled. Arabic version of Patient Health Questionnaire 9 (PHQ-9) was used. Body mass index (BMI) scores were used to classify participants into underweight, average weight, overweight, and obese.Result: It was found that 41.7% of the obese participants have moderate to severe depression, and this result was statistically significant (P = 0.027, 95% CI 1.69-1.98). The prevalence was more marked among young participants (P = 0.001). Other variables such as marital status, the presence of a chronic illness, psychiatric disorders, regular intake of medications, effect of depressive symptoms on daily activity, and the number of years diagnosed with obesity and depression all showed a statistically significant association in the presence of comorbidity of obesity and depression (P < 0.05). Conclusion:The association between depression and obesity is most prominent in young adults aged between 18 to 25 years (11.2%), being single (12.8%), having a BMI of 30 or more for 10 years or more (45.4%), the presence of associated chronic illnesses (17.6%), the presence of associated psychiatric disorder (18.3%) and intake of regular medications (18.3%). Depression and obesity are major health challenges worldwide. Many studies were done to assess the relationship between obesity and depression, but only a few were conducted in Saudi Arabia. This study was done to investigate this relationship. It will help raise awareness about the comorbidity of depression and obesity to address preventative and therapeutic measures.

This editorial addresses evidence based medical practice in forensic psychiatry and particularly in the field of paraphilia. John M. Bradford is a Professor in the Department of Psychiatry and Behavioural Neurosciences, McMaster University. He is an Emeritus Professor at the University of Ottawa where he was a founder of the Royal Ottawa Institute of Mental Health Research. He is a Founder of Forensic Psychiatry, granted by the Royal College of Physicians and Surgeons of Canada. Abdullah H Alqahtani is an Assistant Professor and Consultant Psychiatrist at King Fahd University Hospital, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. He is currently completing a clinical fellowship in forensic psychiatry at McMaster University - St. Joseph’s Healthcare Hamilton. Andrew T. Olagunju is an academic psychiatrist with a Senior Lecturer position at the College of Medicine, University of Lagos, Nigeria. He is also completing a clinical fellowship at McMaster University - St. Joseph’s Healthcare Hamilton.