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Artificial neural network (ANN) models are involved in many applications because of its great computational capabilities. Training of multi-layer perceptron (MLP) is the most challenging problem during the network preparation. Many techniques have been introduced to alleviate this problem. Back-propagation algorithm is a powerful technique to train multilayer feedforward ANN. However, it suffers from the local minima drawback. Recently, meta-heuristic methods have introduced to train MLP like Genetic Algorithm (GA), Particle Swarm Optimization (PSO), Cuckoo Search (CS), Ant Colony Optimizer (ACO), Social Spider Optimization (SSO), Evolutionary Strategy (ES) and Grey Wolf Optimization (GWO). This chapter applied Multi-Verse Optimizer (MVO) for MLP training. Seven datasets are used to show MVO capabilities as a promising trainer for multilayer perceptron. Comparisons with PSO, GA, SSO, ES, ACO and GWO proved that MVO outperforms all these algorithms.

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