The research was conducted in the fields of the Agricultural Technical College / Mosul to combat the weed associated with the barley crop for the winter season 2019/2020 to as a method of integrated control management. The research included three factors: The first factor is the two levels Trifloralin Herbicide (the concentration of 1248 cm3 active substance / e and the comparison treatment) and the second factor is the cultivation distances at two levels (15, 30) cm. As for the third factor, cultivation methods are also at two levels (orthogonal cultivation, conventional cultivation). The experiment was applied according to the system of global experiments in split – split block by designing the complete random sectors with three replicates. The most important results are summarized as follows: The three factors: Trifloralin herbicide and the narrow distance (15) cm between the row and cultivation achieved a significant decrease in the number of narrow-leaf weeds / m2, number of tillers for narrow-leaved weeds / m2, dry weight of the narrow-leaf weeds and the number of broad-leaved weeds, while no significant effect appeared between the two cultivation methods on the dry weight of the broad-leaved weed. The interference between the herbicide and the distance (15) cm, and the interference between the herbicide and orthogonal cultivation, and the interference between the distance (15) cm and orthogonal cultivation, as well as the triple interference between the herbicide and the distance (15) cm orthogonal cultivation, achieved a significant decrease in all studied characteristics.