Single-photon emission computed tomography (SPECT) images can significantly help physicians in diagnosing patients with coronary artery or suspected coronary artery diseases. However, these images are grayscale with qualities that are not readily visible. The objective of this study was to evaluate the effectiveness of different pseudo-coloring algorithms of myocardial perfusion SPECT images. Data were collected using a Siemens Symbia T2 dual-head SPECT/computed tomography (CT) scanner. After pseudo-coloring, the images were assessed both qualitatively and quantitatively. The qualities of different pseudo-color images were examined by three experts, while the images were evaluated quantitatively by obtaining indices such as mean squared error (MSE), peak signal-to-noise ratio (PSNR), normalized color difference (NCD), and structure similarity index metric (SSIM). The qualitative evaluation demonstrated that the warm color map (WCM), followed by the jet color map, outperformed the remaining algorithms in terms of revealing the non-visible qualities of the images. Furthermore, the quantitative evaluation results demonstrated that the WCM had the highest PSNR and SSIM but the lowest MSE. Overall, the WCM could outperform the other color maps both qualitatively and quantitatively. The novelty of this study includes comparing different pseudo-coloring methods to improve the quality of myocardial perfusion SPECT images and utilizing our collected datasets.

The present study aimed to evaluate the effectiveness of different filters in improving the quality of myocardial perfusion single-photon emission computed tomography (SPECT) images. Data were collected using the Siemens Symbia T2 dual-head SPECT/Computed tomography (CT) scanner. Our dataset included more than 900 images from 30 patients. The quality of the SPECT was evaluated after applying filters such as the Butterworth, Hamming, Gaussian, Wiener, and median–modified Wiener filters with different kernel sizes, by calculating indicators such as the signal-to-noise ratio (SNR), peak signal-to-noise ratio (PSNR), and contrast-to-noise ratio (CNR). SNR and CNR were highest with the Wiener filter with a kernel size of 5 × 5. Additionally, the Gaussian filter achieved the highest PSNR. The results revealed that the Wiener filter, with a kernel size of 5 × 5, outperformed the other filters for denoising images of our dataset. The novelty of this study includes comparison of different filters to improve the quality of myocardial perfusion SPECT. As far as we know, this is the first study to compare the mentioned filters on myocardial perfusion SPECT images, using our datasets with specific noise structures and mentioning all the elements necessary for its presentation within one document.