Prostate cancer (PCa) has been reported to be one of the most frequently diagnosed cancers; it accounts for 7.1% of new cases of all cancers and 3.8% of cancer-related deaths worldwide. 1 Risks and associated factors of PCa include age, high androgen levels, overweight, and obesity. 2 In fact, obesity has globally increased to an epidemic level and has been recognized as major health concern; aside from being related to diabetes, hypertension, and cardiovascular disease, it is linked to the development and progression of numerous types of cancers such as ovarian, pancreatic, endometrial, colon, postmenopausal breast, and prostate. 3-5 Additionally, obesity has been associated with aggressive cancer, bad prognosis, poor outcome, and poor survival rate of cancer patients. 6-8 Pathophysiological mechanisms underlying such association