Premenstrual syndrome (PMS) is a common health problem in young women that affects their personal and professional lives. METHOD: This is a cross-sectional study, which was performed at Taibah University, Saudi Arabia, in 2015-2016.This study explores the determinants of PMS and its prevalence, severity and impact on students of medicine and literature respectively. RESULT: We find that medical students suffer less from PMS than literature students. The latter experience more severe symptoms and are highly affected in their routine chores, academic performance and self-care.CONCLUSION: Awareness and education about PMS and its risk factors should be considered for effective management of the syndrome and enhancement of the quality of daily life among Saudi women.