Aim. Innovate a standard for the future model of nursing care at medical-surgical units in Najran University through a training program for the standard of the future model evaluation on studied nurses’ knowledge, attitude about innovation standards, and innovative behavior among nurses. Methods. A quasi-experimental research was used to achieve the study’s goal; the research was carried out at Najran University Hospital at Najran, in the medical and surgical units, as well as outpatient clinics. The sample is a convenience type; 100 nurses were used. Tool. A structured questionnaire sheet was used for data collection that includes nurses’ knowledge, attitude, and individual innovative scale. Results. This reveals the studied nurses related to their individual innovative scale pre- and postintervention. Concerning resistance to change, the mean of them preintervention is x ̅ SD 9.08 ± 2.60 . Concerning opinion leadership, the mean of them postintervention is x ̅ SD 14.32 ± 3.16 . There is a highly significant difference ( p < 0.01 ∗ ∗ ) preintervention as regards all domains listed. Conclusion. The educational program significantly enhances nurses’ knowledge and attitude, according to our present study. Nurses’ innovative skills are also improved by enhancing their knowledge and attitude. Before and after the educational program was implemented, there was a highly positive linear association between the nurses’ knowledge, attitude, and innovative skills at p < 0.01 .